Burn Publications

Abstract BACKGROUND: Hypertrophic scar was first described over 100 years ago; PubMed has more than 1,000 references on the topic. Nevertheless prevention and treatment remains poor, because 1) there has been no validated animal model; 2) human scar tissue, which is impossible to obtain in a controlled manner, has ...

Growing evidence indicates that the melanocortin 1 receptor (MC1R) and its ligand a-melanocyte-stimulating hormone (a-MSH) have other functions in the skin in addition to pigment production. Activation of the MC1R/a-MSH signaling pathway has been implicated in the regulation of both inflammation and extracellular matrix homeostasis. However, little is known ...

A number of factors increase the susceptibility of older adults to burn injury. The majority of studies of older adults have focused on patient and injury factors related to mortality risk. However, little is known about the long-term functional and psychological outcomes of older adults after severe burn. The ...

OBJECTIVE: The current study implemented a four-step process to evaluate the measurement properties of the Perceived Stigmatization Questionnaire (PSQ) and the Social Comfort Questionnaire (SCQ) among long-term pediatric burn survivors. METHODS: First, a series of confirmatory factor analyses (CFAs) compared the hypothesized four-factor model--3 perceived stigmatization factors (absence of ...

This study examined perceptions of stigmatization in a sample of 85 pediatric burn survivors and their parents. Survivors and a parent independently completed the Perceived Stigmatization Questionnaire (PSQ) rating the frequency that the child experienced three types of stigmatizing behaviors: absence of friendly behavior, confused and staring behavior, and ...

OBJECTIVE: Previous studies have suggested a link between heart rate (HR) following trauma and the development of posttraumatic stress disorder (PTSD). This study expands on previous work by evaluating HR in burn patients followed longitudinally for symptoms of acute stress disorder (ASD) and PTSD. METHOD: Data were collected from ...

PURPOSE OF REVIEW: The hypermetabolic response in critically ill patients is characterized by hyperdynamic circulatory, physiologic, catabolic and immune system responses. Failure to satisfy overwhelming energy and protein requirements after, and during critical illness, results in multiorgan dysfunction, increased susceptibility to infection, and death. Attenuation of the hypermetabolic response ...

Cardiac stress, mediated by increased catecholamines, is the hallmark of severe burn injury typified by marked tachycardia, increased myocardial oxygen consumption, and increased cardiac output (CO). It remains one of the main determinants of survival in large burns. Currently, it is unknown for how long cardiac stress persists after ...

BACKGROUND: In the treatment of burns, patients' own skin is the preferred material to cover burn wounds, resulting in the need to create a donor site wound. Enhancement of healing of the donor site wound would be beneficial in burn patients. Insulin, an anabolic agent, is used routinely to ...

BACKGROUND: Main contributors to adverse outcomes in severely burned pediatric patients are profound and complex metabolic changes in response to the initial injury. It is currently unknown how long these conditions persist beyond the acute phase post-injury. The aim of the present study was to examine the persistence of ...

INTRODUCTION: Maximal oxygen uptake (VO2 peak) is an indicator of cardiorespiratory fitness, but requires expensive equipment and a relatively high technical skill level. PURPOSE: The aim of this study is to provide a formula for estimating VO2 peak in burned children, using information obtained without expensive equipment. METHODS: Children, ...

The Growth Hormone and Insulin-like Growth Factor-1 (IGF-1) axis plays a pivotal role in critical illness, with a derangement leading to profound changes in metabolism. Protein wasting with skeletal muscle loss, delayed wound healing, and impaired recovery of organ systems are some of the most feared consequences. The use ...

OBJECTIVE: Severe thermal injury induces inflammatory and hypermetabolic responses that are associated with morbidity and mortality. However, it is not well-documented whether the causes of burns affect inflammation, hypermetabolism, and morbidity. The aim of the present study was to determine whether there is a difference in degree of inflammation, ...

Study examined the long-term functional and psychological outcomes of older adults after burn injury. The authors analyzed the outcomes of 737 patients aged 55 years or older who were enrolled and followed in the National Institute on Disability and Rehabilitation Research burn program. Change in living situation as well ...

Study examined the organization and current practices in physical rehabilitation across burn centers. An online survey was used to collect information regarding: (1) logistics of the burn center, (2) inpatient and outpatient treatment of patients with burn injury, and (3) specific protocols in the treatment of a few complications ...

Study compared a low fat/high-carbohydrate diet and a high-fat diet on morbidity and mortality outcomes in severely burned children. Nine hundred forty-four children with burns on 40 percent or more of their total body surface area (TBSA) were divided into two groups: 518 patients receiving Vivonex T.E.N. (low-fat/high-carbohydrate diet) ...

This review article discusses the more recent advances in therapeutic strategies to attenuate the hypermetabolic response and its associated insulin resistance postburn. The hypermetabolic response in critically ill patients is characterized by hyperdynamic circulatory, physiologic, catabolic, and immune system responses. Failure to satisfy overwhelming energy and protein requirements after, ...

Study examined the impact of face burns on the psychosocial adjustment of pediatric burn survivors and their parents during the first two years after injury. Subjects were 390 children less than 18 years old at injury, admitted for burn treatment from September 2001 to December 2004. Psychosocial functioning was ...

Study compared perceptions of stigmatization experienced by 85 pediatric burn survivors with those of their parents. Among the burn survivors, 38 percent were female, 44 percent had facial scars, and the median number of surgical procedures was two. Survivors and a parent independently completed the Perceived Stigmatization Questionnaire (PSQ), ...

Study examined the effect of a steady state amino acid (AA) infusion on leg muscle protein turnover and whole-body muscle and whole-body nonmuscle protein breakdown rates in pediatric burn patients at 6 month postinjury compared with that of healthy subjects. A total of 10 pediatric patients and 5 healthy ...