Burn Publications

Article reviews the current understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management. Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. Despite recent advances in critical care and the ...

Study assessed the effects of gene expression or intracellular signaling in paralyzed muscles of men with long-standing spinal cord injury (SCI). Specifically, it examined the expression of genes (TNFαR, TNFα, IL-6R, IL-6, TWEAK, TWEAK R, atrogin-1, and MuRF1) and abundance of intracellular signaling proteins (TWEAK, TWEAK R, NF-κB, and p-p65/p-50/105) ...

Article reviews the evidence for the utility of rehabilitative exercise training (RET) in restoring physiological function in burn survivors. Severe burn trauma results in persistent skeletal muscle catabolism and prolonged immobilization. The authors hypothesize that structured RET is a safe and effective strategy to restore lean body mass and ...

Study examined the long-term quality of life (QOL) of pediatric burn survivors with and without inhalation injuries. It was hypothesized that patients with inhalation injury would report more disability and lower QOL. Participants included 51 patients with inhalation injury and 72 without inhalat ion injury who had burns ...

Study analyzed the variation in rehabilitation utilization by state of hospitalization for patients hospitalized with burn injury. This retrospective cohort study used nationally collected data over a 10-year period (2001 to 2010), from the Healthcare Cost and Utilization Project State Inpatient Databases. A total of 57,968 patients hospitalized for ...

Study investigated whether the Vancouver Scar Scale (VSS) can be used to define hypertrophic scarring (HTS) in an objective, reliable manner. An online survey sent to 1,000 burn care providers asked respondents what VSS score indicates HTS and asked them to score scar photos using the VSS. Receiver operating ...

Study evaluated the efficacy of utilizing an expanded care coordinator (ECC) to supplement existing outpatient burn rehabilitation services. In this between-group, single-blind, randomized controlled trial, the 41 patients in the control group received standard outpatient care and the 40 experimental group patients received additional services provided by the ECC, ...

Article introduces the Rehabilomics framework, a translational model that provides an “-omics” overlay to the scientific study of rehabilitation processes and multidimensional outcomes. Despite many people having similar clinical presentation, demographic factors, and clinical care, outcome can differ for those sustaining significant injury such as spinal cord injury (SCI) and ...

Study investigated whether expression of interleukin 8 (IL-8), a major mediator for inflammatory responses, can be used to predict post-burn sepsis, infections, and mortality. Plasma cytokines, acute-phase proteins, constitutive proteins, and hormones were analyzed during the first 60 days after injury from 468 pediatric burn patients. Demographics and clinical ...

Study examined the skeletal muscle protein synthesis (MPS) rate of burned children over a period of 24 months after injury and identified predictors that influence this response. Eighty-seven children with 40 percent or greater total body surface area (TBSA) burned participated in stable isotope infusion studies at 1, 2, ...

Study assessed the psychometric properties of the full-version Community Integration Questionnaire (CIQ-15) in the adult burn population. Data were obtained from a multicenter longitudinal data set of 492 burn survivors. The questionnaire items were evaluated for clinical and substantive relevance; validation procedures were conducted on different samples of the ...

Study identified predictors for discharge to independent versus non-independent living status in older patients hospitalized for burns. Patient, injury, and treatment outcomes data were collected from 591 patients aged ≥55 years who were treated and discharged alive from three burn centers participating in the Burn Model Systems project from ...

Study identified and analyzed clinical factors that predict heterotopic ossification (HO), the ectopic formation of lamellar bone, in adults with burn injuries. Data were collected from six high-volume burn centers in the Burn Injury Model Systems (BMS) database. The BMS, funded by the National Institute on Disability, Independent Living ...

Study examined the effect of amantadine on irritability in people in the post-acute period after traumatic brain injury (TBI). One hundred sixty-eight subjects with irritability 6 or more months post-TBI were enrolled in a parallel-group, randomized, double-blind, placebo-controlled trial receiving either 100 milligrams of amantadine every morning and noon or ...

Study examined the effects of low and high tidal volume ventilation on the number of ventilator days, ventilation pressures, and incidence of atelectasis, pneumonia, and acute respiratory distress syndrome (ARDS) in pediatric burned patients with inhalation injury. Inhalation injury was diagnosed by bronchoscopy in 932 pediatric burned patients who ...