Year, Volume, Issue, Page(s):, 43, 3, 222-227
Study investigated whether expression of interleukin 8 (IL-8), a major mediator for inflammatory responses, can be used to predict post-burn sepsis, infections, and mortality. Plasma cytokines, acute-phase proteins, constitutive proteins, and hormones were analyzed during the first 60 days after injury from 468 pediatric burn patients. Demographics and clinical outcome variables (length of stay, infection, sepsis, multiple organ failure [MOF], and mortality) were recorded. A cutoff level for IL-8 was determined using receiver operating characteristic analysis. Receiver operating characteristic analysis identified a cutoff level of 234 picograms per milliliter for IL-8 for survival. Patients were grouped according to their average IL-8 levels relative to this cutoff and stratified into high (133 patients) and low (335 patients) groups. In the low group, regression analysis revealed a significant predictive value of IL-8 to percent of total body surface area burned and incidence of MOF. In the high group, IL-8 levels were able to predict sepsis. In the high group, elevated IL-8 was associated with increased inflammatory and acute-phase responses compared with the low group. High levels of IL-8 correlated with increased MOF, sepsis, and mortality. These data suggest that serum levels of IL-8 may be a valid biomarker for monitoring sepsis, infections, and mortality in burn patients.
Kraft, Robert, Herndon, David N., Finnerty, Celeste C., Cox, Robert A., Song, Juquan, Jeschke, Marc G.