Burn Publications

The objective of the study is to evaluate the validity and reliability of the Itch Man Scale developed in 2000 by Blakeney and Marvin in assessing the intensity of itch in the pediatric burn patient. Forty-five patients (31 males and 14 females; average age 9.9 ± 5.0 years; and ...

HYPOTHESIS: Obesity in?uences metabolism and increases the incidence of clinical complications and worsens outcomes in pediatric burn patients. DESIGN: Retrospective, single-center study. SUBJECTS: In all, 592 severely burned pediatric patients who had burns covering more than 30% of the total body surface area and who were treated between 2001 ...

BACKGROUND: Patient survival after severe burn injury is largely determined by burn size. Modern developments in burn care have greatly improved survival and outcomes. However, no large analysis of outcomes in paediatric burn patients with present treatment regimens exists. This study was designed to identify the burn size associated ...

BACKGROUND: Burn induces a hypermetabolic state characterized by alterations in protein metabolism, which is associated with increased morbidity and mortality. Eukaryotic elongation factor 2 (eEF2) plays a crucial role in regulating protein synthesis in many diseases, but whether it participates in burn-induced hypermetabolism is unclear. The aim of this ...

Fenofibrate is a peroxisome proliferator activated receptor alpha agonist that contains both pro and anti-inflammatory properties, and has been used in the treatment of dyslipidemia and diabetes for decades. Its receptors are expressed in the liver, skeletal muscle, cardiac, enteric, and renal cells, which allow it to provide systemic ...

Article reviews changes in burn care at the Harborview Burn Center in Seattle, WA, from 1974 to 2009. It reports results and include observations on changes in numbers of standard and short-stay admissions, age distribution, transport patterns, percent of total body surface area burned, race/ethnicity, payer status, fluid creep, ...

OBJECTIVE: Previous studies have suggested a link between heart rate (HR) following trauma and the development of posttraumatic stress disorder (PTSD). This study expands on previous work by evaluating HR in burn patients followed longitudinally for symptoms of acute stress disorder (ASD) and PTSD. METHOD: Data were collected ...

Growing evidence indicates that the melanocortin 1 receptor (MC1R) and its ligand a-melanocyte-stimulating hormone (a-MSH) have other functions in the skin in addition to pigment production. Activation of the MC1R/a-MSH signaling pathway has been implicated in the regulation of both inflammation and extracellular matrix homeostasis. However, little is known about ...

Study examined the organization and current practices in physical rehabilitation across burn centers. An online survey was used to collect information regarding: (1) logistics of the burn center, (2) inpatient and outpatient treatment of patients with burn injury, and (3) specific protocols in the treatment of a few complications ...

Study compared a low fat/high-carbohydrate diet and a high-fat diet on morbidity and mortality outcomes in severely burned children. Nine hundred forty-four children with burns on 40 percent or more of their total body surface area (TBSA) were divided into two groups: 518 patients receiving Vivonex T.E.N. (low-fat/high-carbohydrate diet) ...

This review article discusses the more recent advances in therapeutic strategies to attenuate the hypermetabolic response and its associated insulin resistance postburn. The hypermetabolic response in critically ill patients is characterized by hyperdynamic circulatory, physiologic, catabolic, and immune system responses. Failure to satisfy overwhelming energy and protein requirements after, ...

Study examined the impact of face burns on the psychosocial adjustment of pediatric burn survivors and their parents during the first two years after injury. Subjects were 390 children less than 18 years old at injury, admitted for burn treatment from September 2001 to December 2004. Psychosocial functioning was ...

Study compared perceptions of stigmatization experienced by 85 pediatric burn survivors with those of their parents. Among the burn survivors, 38 percent were female, 44 percent had facial scars, and the median number of surgical procedures was two. Survivors and a parent independently completed the Perceived Stigmatization Questionnaire (PSQ), ...

Study examined the effect of a steady state amino acid (AA) infusion on leg muscle protein turnover and whole-body muscle and whole-body nonmuscle protein breakdown rates in pediatric burn patients at 6 month postinjury compared with that of healthy subjects. A total of 10 pediatric patients and 5 healthy ...

Study evaluated whether oxandrolone treatment affects mechanisms of protein turnover in skeletal muscle in response to amino acid (AA) infusion and on whole-body protein breakdown in pediatric burn patients 6 months postinjury. At the time of admission, patients were randomized to control or oxandrolone treatments. Clinically, oxandrolone has been ...

Article discusses the epidemiology and risk factors, mechanisms of injury, clinical assessment, and methods of prevention associated with pediatric burn injuries. Burns are the third most frequent cause of childhood injury resulting in death, behind motor vehicle accidents and drowning. Burn injuries account for the greatest length of stay ...

Article reviews evidence from clinical and laboratory research studies exploring the use of virtual reality (VR) to control pain in burn patients undergoing painful medical procedures. VR analgesia has been demonstrated in burn patients both during daily wound care and during physical therapy. Burn patients report 35 to 50 ...

Study reports the differential transcriptome over time and the functional genomics unique to Week 20 post wounding from the deep cones/fat domes in the Duroc/Yorkshire porcine model of fibroproliferative scarring following shallow and deep partial thickness wounds. A system was assembled that permits the study of genome-wide gene expression ...

Study assessed psychometric properties of the brief COPE (BCOPE) in hospitalized patients with burn injury. The BCOPE is a 28-item measure developed from the full-version COPE inventory (60 items) to provide an efficient means of assessing coping behaviors. A total of 362 participants admitted to the hospital with a ...

Study investigated the role of the melanocortin 1 receptor (MC1R) and its ligand a-melanocyte-stimulating hormone (a-MSH) in the regulation of inflammatory and fibroproliferative responses to cutaneous injury. Specifically, the authors report the localization of the MC1R/a-MSH signaling in murine cutaneous wounds, human acute burns, and hypertrophic scars. During murine ...