Burn Publications

Study evaluated whether oxandrolone treatment affects mechanisms of protein turnover in skeletal muscle in response to amino acid (AA) infusion and on whole-body protein breakdown in pediatric burn patients 6 months postinjury. At the time of admission, patients were randomized to control or oxandrolone treatments. Clinically, oxandrolone has been ...

Article discusses the epidemiology and risk factors, mechanisms of injury, clinical assessment, and methods of prevention associated with pediatric burn injuries. Burns are the third most frequent cause of childhood injury resulting in death, behind motor vehicle accidents and drowning. Burn injuries account for the greatest length of stay ...

Article reviews evidence from clinical and laboratory research studies exploring the use of virtual reality (VR) to control pain in burn patients undergoing painful medical procedures. VR analgesia has been demonstrated in burn patients both during daily wound care and during physical therapy. Burn patients report 35 to 50 ...

Study reports the differential transcriptome over time and the functional genomics unique to Week 20 post wounding from the deep cones/fat domes in the Duroc/Yorkshire porcine model of fibroproliferative scarring following shallow and deep partial thickness wounds. A system was assembled that permits the study of genome-wide gene expression ...

Study assessed psychometric properties of the brief COPE (BCOPE) in hospitalized patients with burn injury. The BCOPE is a 28-item measure developed from the full-version COPE inventory (60 items) to provide an efficient means of assessing coping behaviors. A total of 362 participants admitted to the hospital with a ...

Study investigated the role of the melanocortin 1 receptor (MC1R) and its ligand a-melanocyte-stimulating hormone (a-MSH) in the regulation of inflammatory and fibroproliferative responses to cutaneous injury. Specifically, the authors report the localization of the MC1R/a-MSH signaling in murine cutaneous wounds, human acute burns, and hypertrophic scars. During murine ...

Study examined workers who were hospitalized with work-related burn injuries and their psychiatric sequelae in Washington State. Psychiatric sequelae of interest were depression, posttraumatic stress disorder, and other anxiety disorders. Workers' compensation claims for burn patients from Washington State hospitalized from January 2001 through April 2008 were identified. The ...

Psychological adjustment after a major burn injury is a significant concern to providers and patients alike. Although efforts have been made to identify associated risk factors, little is known about heterogeneity in the levels or trajectories of adjustment in this population. This study used a novel application of Growth ...

Increased catecholamine (CA) levels after severe burn are associated with stress, inflammation, hypermetabolism and impaired immune function. The CA secretion profiles in burned patients are not well described. Mechanisms, duration and extent of CA surge are unknown. The purpose of this large unicenter study was to evaluate the extent ...

Severely burned patients typically experience a systemic response expressed as increased metabolism, inflammation, alteration of cardiac and immune function, and associated hyperglycemia. Hyperglycemia has been associated with an increased risk of morbidity and mortality in critically ill patients. Until recently and for many years, hyperglycemia has been expectantly managed ...

This study sought to clarify the prospective and concurrent associations of posttraumatic stress disorder (PTSD) and pain with functioning and disability after burn injury. The sample was composed of consecutive patients admitted to a regional burn center with major burn injuries (N = 171) who were followed at 1, ...

Psychological adjustment after a major burn injury is a significant concern to providers and patients alike. Although efforts have been made to identify associated risk factors, little is known about heterogeneity in the levels or trajectories of adjustment in this population. This study used a novel application of Growth ...

Pressure garment therapy is standard of care for prevention and treatment of hypertrophic scarring after burn injury. Nevertheless there is little objective data that confirms effectiveness. The purpose of this study was to determine the effectiveness of pressure garment therapy with objective data obtained with a randomized within-wound comparison. ...

BACKGROUND: The aim of the study was to compare a low fat/high-carbohydrate diet and a high-fat diet on clinical outcomes by a retrospective cohort study. METHODS: Nine hundred forty-four children with burns = 40% of their total body surface area (TBSA) were divided into two groups: patients receiving Vivonex ...

Autografting of burn wounds results in generation of donor site wounds. Here we measured donor site wound protein fractional synthesis rate (FSR) in a burn pediatric population and showed that FSR increases over time postsurgery and correlates with the length of hospital stay (LOS) normalized for total body surface ...

OBJECTIVE: Little is known about sexual attitudes and behaviors of adults burned as children. We hypothesized that survivors with large burn scars would have differences in sexual attitudes and behaviors from their unburned counterparts. METHODS: Ninety-two young adults (50 males and 42 females), ages 21.0 ± 2.7 years old, ...

Persistent and extensive skeletal muscle catabolism is characteristic of severe burns. Whole body protein metabolism, an important component of this process, has not been measured in burned children during the long-term convalescent period. The aim of this study was to measure whole body protein turnover in burned children at ...