Model System:

Burn

Reference Type:

Journal

Accession No.:

J75762

Journal:


Journal of Burn Care And Research (formerly Journal of Burn Care & Rehabilitation)

Year, Volume, Issue, Page(s):

, 37, 5, 273-277

Publication Website:

Abstract:

Study investigated whether the administration of oxandrolone, a synthetic testosterone derivative, will improve pulmonary function in burned pediatric subjects. Lung volumes and spirometry were assessed in 54 burned subjects during scheduled outpatient clinic visits 6 months post burn. The subjects were previously randomized to either the control arm or the oxandrolone arm (0.1 mg/kg twice/day for 12 months) of a larger clinical trial. Maximum voluntary ventilation (MVV), the ratio between forced expiratory volume and forced vital capacity, and diffusion capacity were measured 6 months following burn injury, and results were compared between burned subjects with and without oxandrolone administration. Maximum expired ventilation (VEmax) was also measured in a subset of burned subjects who underwent a maximal exercise treadmill test. Results showed that subjects treated with oxandrolone had a significantly higher MVV. During maximal exercise, subjects treated with oxandrolone had a significantly higher VEmax compared with untreated subjects. These findings indicate that the administration of oxandrolone was associated with improved lung function in pediatric burned patients

Author(s):


Sousse, Linda E., Herndon, David N., Mlcak, Ronald P., Lee, Jong O., Andersen, Clark R., Zovath, Andrew J., Finnerty, Celeste C., Suman, Oscar E.

Participating Centers: