Five-year outcomes after long-term oxandrolone administration in severely burned children: A randomized clinical trial
Model System:
BurnReference Type:
JournalAccession No.:
J75763Journal:
Shock
Year, Volume, Issue, Page(s):
, 45, 4, 367-374Publication Website:
Abstract:
Study investigated whether administration of oxandrolone for 2 years yields greater effects on bone mineral content (BMC), bone mineral density (BMD), and growth in 119 hospitalized children with severe burn injury (30 percent or more total body surface area burned). Eighty four patients were randomized to the control group, and 35 patients were randomized to receive oxandrolone twice daily for 24 months (long-term oxandrolone group). Height, weight, BMC, and BMD were recorded annually through 5 years postinjury. The long-term administration of oxandrolone for 16 months postburn significantly increased whole-body (WB) BMC and lumbar spine (LS) BMC; these effects were significantly pronounced for a longer time in patients who were in growth spurt years (7-18 years). When adjusted for height, sex, and age, LS-BMD was found to significantly increase with long-term oxandrolone administration. Fewer patients receiving oxandrolone exhibited LS-BMD z scores below -2.0 as compared with controls, indicating a significantly reduced risk for future fracture with oxandrolone administration. Long-term oxandrolone patients had significantly greater height velocity than controls throughout the first 2 years. No adverse side effects were attributed to the long-term administration of oxandrolone. A comparison of the current patients receiving long-term oxandrolone to previously described patients receiving 12 months of oxandrolone revealed that long-term oxandrolone administration imparted significantly greater increases in WB-BMC, WB-BMD, and LS-BMD. Results indicate that administering oxandrolone for up to 2 years following severe burn injury results in greater improvements in BMC, BMD, and height velocity.
Author(s):
Reeves, Patrick T., Herndon, David N., Tanksley, Jessica D., Jennings, Kristofer, Klein, Gordon L., Mlcak, Ronald P., Clayton, Robert P., Crites, Nancy N., Hays, Joshua P., Andersen, Clark, Lee, Jong O., Meyer, Walter , Suman, Oscar E., Finnerty, Celeste C.