Model System:

Burn

Reference Type:

Journal

Accession No.:

J73520

Journal:


Journal of Trauma and Acute Care Surgery

Year, Volume, Issue, Page(s):

, 78, 4, 816-822

Publication Website:

Abstract:

Study examined the skeletal muscle protein synthesis (MPS) rate of burned children over a period of 24 months after injury and identified predictors that influence this response. Eighty-seven children with 40 percent or greater total body surface area (TBSA) burned participated in stable isotope infusion studies at 1, 2, and approximately 4 weeks after burn and at 6, 12, and 24 months after injury to determine skeletal muscle protein fractional synthesis rate (FSR). Generalized estimating equations with log link normal distribution were applied to account for clustering of patients and control for patient characteristics. Patients had large and deep burns. Muscle protein FSR was elevated throughout the first 12 months after burn compared with established values from healthy young adults. Muscle protein FSR was lower in boys, in children older than 3 years, and when burns were greater than 80 percent TBSA. The results of this study indicate that MPS is elevated for at least 1 year after injury, suggesting that greater muscle protein turnover is a component of the long-term pathophysiologic response to burn trauma. MPS is highly affected by sex, age, and burn size in severely burned children. These findings may explain the divergence in net protein balance and lean body mass in different populations of burn patients.

Author(s):


Diaz, Eva C., Herndon, David N., Lee, Jinhyung, Porter, Craig, Cotter, Matthew, Suman, Oscar E., Sidossis, Labros S., Borsheim, Elisabet

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