Model System:

Burn

Reference Type:

Journal

Accession No.:

J78244

Journal:


Journal of Burn Care And Research (formerly Journal of Burn Care & Rehabilitation)

Year, Volume, Issue, Page(s):

, 38, 4, 243-250

Publication Website:

Abstract:

Study investigated whether the coadministration of oxandrolone and propranolol alters plasma propranolol concentrations. Propranolol, is a beta blocker used to reduce resting heart rate and cardiac work caused by elevated circulating catecholamines. Oxandrolone, a testosterone mimetic, promotes protein synthesis and anabolism to counter muscle wasting; testosterone administration is known to alter beta-adrenergic receptor-mediated signaling. Coadministration of these drugs is expected to synergistically improve patient outcomes. Ninety-two pediatric patients with burns covering at least 30 percent of the total body surface area were randomized to receive propranolol or oxandrolone plus propranolol. Plasma propranolol concentrations were determined following two dosing strategies: Q6 (liquid formulation) and Q24 (extended-release capsule). Samples were drawn before drug administration and at regular intervals throughout the next two dosing periods. Heart rate and blood pressure were recorded throughout the study. Propranolol half-life was 3.3 hours for the Q6 drug dosing frequency and 11.2 hours for the Q24 strategy. The percentage of predicted heart rate declined by 2.8 percent for each doubling of the propranolol concentration in the Q6 dosing schedule. The percentage of predicted heart rate declined by 2.5 percent for each doubling of propranolol concentration on the Q24 dosing schedule. Maximum and minimum propranolol plasma concentrations were similar with either dosing regimen. The results indicate that the addition of oxandrolone did not affect any of the measured parameters; oxandrolone coadministration did not alter propranolol’s plasma concentration, half-life, or effect on heart rate.

Author(s):


Guillory, Ashley N., Herndon, David N., Silva, Michael B., Andersen, Clark R., Suman, Oscar E., Finnerty, Celest C.

Participating Centers: