Model System:

Burn

Reference Type:

Journal article

Accession No.:

J81109

Journal:

Medicine and Science in Sports and Exercise

Year, Volume, Issue, Page(s):

, 49, 10, 1993-2000

Publication Website:

Abstract:

Study assess the cardiovascular response to submaximal exercise in children nearly 1 year after burn injury. It was hypothesized that burn injury would lower cardiac output (Q) and stroke volume (SV) during submaximal exercise in burned children compared with non-burned healthy children matched for age and aerobic capacity. Five children with 49 percent total body surface area (TBSA) burned and eight similar non-burned controls with comparable exercise capacity (peak oxygen consumption [peak VO2]) participated. The exercise protocol entailed a pre-exercise (pre-EX) rest period followed by 3-minute exercise stages at two stages of submaximal exercise: 20 and 50 work rate (W). VO2, heart rate (HR), Q (via non-rebreathing), SV (Q/HR), and arteriovenous oxygen difference were the primary outcome variables. A two-way factorial analysis of variance (group-by-exercise), found that Q was about 27 percent lower in the burned than the non-burned group at 20 and 50 W of exercise. SV did not change from rest to exercise in burned children but increased by about 24 percent in the non-burned group. Neither arteriovenous oxygen nor VO2 differed between groups at rest or exercise, but HR response to exercise was reduced in the burn group (group-by-exercise interaction). When normalized to TBSA, SV (index) was similar between groups; however, Q (index) remained attenuated in the burned group (group-by-exercise interaction). The findings suggest that burned children have a weaker cardiovascular response to submaximal exercise. Further investigation of hemodynamic function during exercise will provide insights important for cardiovascular rehabilitation in burned children.

Author(s):

Rivas, Eric|Herndon, David N.|Beck, Kenneth C.|Suman, Oscar E.|

Participating Centers: