Burn Publications

Study determined the temporal relationship between burn trauma and mitochondrial function in murine skeletal muscle local to and distal from burn wounds. Male mice (8-10 weeks old) were burned by submersion of the dorsum in water to create a full thickness burn on approximately 30 percent of the body. ...

Study evaluated the efficacy of a 12-week community-based exercise training rehabilitation program (COMBEX) in improving lean mass, muscle strength, and aerobic capacity in children with severe burns. Thirty-four pediatric patients (aged 7–18 years) with burns covering 30 percent or more of their total body surface area (TBSA) were randomized ...

Study assessed the effects of exercise combined with whole-body vibration (WBV) on bone mass, lean mass (LM), and muscle strength in children recovering from burns. Nineteen children with ≥30 percent total body surface area (TBSA) burns were randomly assigned to a 6-week exercise regimen either alone (EX) or in ...

Study assessed the feasibility of using an exoskeleton-based interactive gaming system to measure continuous joint motion data.in the rehabilitation of upper-extremity burn contractures. Eight subjects with a history of burn injury and upper-extremity contractures were recruited from the outpatient clinic of a regional inpatient rehabilitation facility. Subjects used an ...

Study investigated whether administration of oxandrolone for 2 years yields greater effects on bone mineral content (BMC), bone mineral density (BMD), and growth in 119 hospitalized children with severe burn injury (30 percent or more total body surface area burned). Eighty four patients were randomized to the control group, ...

Study explored how hypermetabolism contributes to muscle wasting in burn patients. It was hypothesized that oxidative stress, cytosolic protein degradation, and mitochondrial stress as a result of hypermetabolism contribute to postburn muscle cachexia. Fourteen patients with burns covering more than 30 percent of their total body surface area were ...

Improvements in acute burn care have enabled patients to survive massive burns that would have once been fatal. Now, up to 70 percent of patients develop hypertrophic scars after burns. Patients with these massive burns have extensive scarring and contractures, itch, and pain. They are dissatisfied with their appearance ...

This review article discusses the epidemiology of burn infections, defines degrees of severity of infection, outlines the major organisms associated with burn wounds, and describes the specific organs and tissues susceptible to infection. The authors also discuss strategies for surveillance, sampling, and infection control in the burn intensive care ...

Study examined the feasibility of a computerized, burn-specific patient-reported outcome measures, the Young Adult Burn Outcome Questionnaire (YABOQ), with real-time benchmarking feedback in a burn outpatient practice. The YABOQ was redesigned for formatting and presentation purposes, transcribed to a computerized format, and administered to young adult burn survivors via ...

Article provides a brief overview of the purpose of and information included in the Burn Injury Model System (BMS) National Database. The BMS collects informative data on both adult and pediatric survivors following a major burn. It also collects information on return to work, school, and participation in the ...

Study investigated whether the administration of oxandrolone, a synthetic testosterone derivative, will improve pulmonary function in burned pediatric subjects. Lung volumes and spirometry were assessed in 54 burned subjects during scheduled outpatient clinic visits 6 months post burn. The subjects were previously randomized to either the control arm or ...

Study compared long-term functional outcome between severely burned children who either participated or did not participate in a 12-week exercise program. A total of 125 severely burned children (mean age 12 years) who received no long-term anabolic drugs chose between a voluntary exercise program (EX-group) and no exercise (NoEX-group) ...

Study examined skeletal muscle mitochondrial respiratory capacity and function in healthy individuals and in burn victims for up to 2 years postinjury. Muscle biopsies were collected from 16 healthy men and from 69 children with burns encompassing at least 30 percent of their total body surface area. Seventy-nine biopsies ...

This systematic review of the literature was conducted to identify evidence to support the use of measures of depression for adults with burn injuries. The goal was to determine the most reliable, valid, and efficient means of identifying adults with symptoms of depression including major depressive disorder. Established guidelines ...

Study investigated the effect of Clostridium difficile-associated diarrhea (CDAD) on morbidity and mortality in severely burned children and identified CDAD risk factors. After retrospective review of 2,840 records, 288 pediatric burn patients were identified as having diarrhea, defined as stool output of more than 10 milliliters per kilogram per ...

Article reviews the current understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management. Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. Despite recent advances in critical care and the ...

Study examines the incidence and severity of contractures in a large, multicenter, pediatric burn population and determined the associated risk factors for the development of contractures. Data from the National Institute on Disability and Rehabilitation Research Burn Model System database, for pediatric (younger than 18 years) burn survivors from ...

This study developed a scoring system that stratifies burn patients at the time of hospital admission according to risk of developing heterotopic ossification (HO), the development of abnormal bone in the soft tissue. HO in burns is an uncommon but severely debilitating problem with a poorly understood mechanism and ...

Study examined the effect of propranolol on hemodynamic parameters assessed using the PiCCO (Pulse index Continuous Cardiac Output) system in burned children. The study analyzed hemodynamic data from 121 patients who were randomized to receive either propranolol or placebo (control), which was initiated as a prospective randomized controlled trial. ...

Study investigated whether the combined administration of oxandrolone and propranolol attenuates growth arrest and improves the rate of growth, compared to the administration of oxandrolone or propranolol alone, in severely burned children. In this prospective, randomized study of 612 burned children (males between the ages of 0.5 and 14 ...