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Burn Publications

Publication Year
2016

Differential acute and chronic effects of burn trauma on murine skeletal muscle bioenergetics

Study determined the temporal relationship between burn trauma and mitochondrial function in murine skeletal muscle local to and distal from burn wounds. Male mice (8-10 weeks old) were burned by submersion of the dorsum in water to create a full thickness burn on approximately 30 percent of the body. ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Effects of community-based exercise in children with severe burns: A randomized trial

Study evaluated the efficacy of a 12-week community-based exercise training rehabilitation program (COMBEX) in improving lean mass, muscle strength, and aerobic capacity in children with severe burns. Thirty-four pediatric patients (aged 7–18 years) with burns covering 30 percent or more of their total body surface area (TBSA) were randomized ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Effects of whole-body vibration exercise on bone mineral content and density in thermally injured children

Study assessed the effects of exercise combined with whole-body vibration (WBV) on bone mass, lean mass (LM), and muscle strength in children recovering from burns. Nineteen children with ≥30 percent total body surface area (TBSA) burns were randomly assigned to a 6-week exercise regimen either alone (EX) or in ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Feasibility of an exoskeleton-based interactive video game system for upper extremity burn contractures

Study assessed the feasibility of using an exoskeleton-based interactive gaming system to measure continuous joint motion data.in the rehabilitation of upper-extremity burn contractures. Eight subjects with a history of burn injury and upper-extremity contractures were recruited from the outpatient clinic of a regional inpatient rehabilitation facility. Subjects used an ...
Boston-Harvard Burn Injury Model System
Publication Year
2016

Five-year outcomes after long-term oxandrolone administration in severely burned children: A randomized clinical trial

Study investigated whether administration of oxandrolone for 2 years yields greater effects on bone mineral content (BMC), bone mineral density (BMD), and growth in 119 hospitalized children with severe burn injury (30 percent or more total body surface area burned). Eighty four patients were randomized to the control group, ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma

Study explored how hypermetabolism contributes to muscle wasting in burn patients. It was hypothesized that oxidative stress, cytosolic protein degradation, and mitochondrial stress as a result of hypermetabolism contribute to postburn muscle cachexia. Fourteen patients with burns covering more than 30 percent of their total body surface area were ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Hypertrophic scarring: The greatest unmet challenge following burn injury

Improvements in acute burn care have enabled patients to survive massive burns that would have once been fatal. Now, up to 70 percent of patients develop hypertrophic scars after burns. Patients with these massive burns have extensive scarring and contractures, itch, and pain. They are dissatisfied with their appearance ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Infection in burns

This review article discusses the epidemiology of burn infections, defines degrees of severity of infection, outlines the major organisms associated with burn wounds, and describes the specific organs and tissues susceptible to infection. The authors also discuss strategies for surveillance, sampling, and infection control in the burn intensive care ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Is real-time feedback of burn-specific patient-reported outcome measures in clinical settings practical and useful? A pilot study implementing the young adult burn outcome questionnaire

Study examined the feasibility of a computerized, burn-specific patient-reported outcome measures, the Young Adult Burn Outcome Questionnaire (YABOQ), with real-time benchmarking feedback in a burn outpatient practice. The YABOQ was redesigned for formatting and presentation purposes, transcribed to a computerized format, and administered to young adult burn survivors via ...
Boston-Harvard Burn Injury Model System
Publication Year
2016

Letter to the editor #2: Description of the burn model system national database sample

Article provides a brief overview of the purpose of and information included in the Burn Injury Model System (BMS) National Database. The BMS collects informative data on both adult and pediatric survivors following a major burn. It also collects information on return to work, school, and participation in the ...
Northwest Regional Burn Model System
Publication Year
2016

Long-term administration of oxandrolone improves lung function in pediatric burned patients

Study investigated whether the administration of oxandrolone, a synthetic testosterone derivative, will improve pulmonary function in burned pediatric subjects. Lung volumes and spirometry were assessed in 54 burned subjects during scheduled outpatient clinic visits 6 months post burn. The subjects were previously randomized to either the control arm or ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Long-term effects of physical exercise during rehabilitation in patients with severe burns

Study compared long-term functional outcome between severely burned children who either participated or did not participate in a 12-week exercise program. A total of 125 severely burned children (mean age 12 years) who received no long-term anabolic drugs chose between a voluntary exercise program (EX-group) and no exercise (NoEX-group) ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Long-term skeletal muscle mitochondrial dysfunction is associated with hypermetabolism in severely burned children

Study examined skeletal muscle mitochondrial respiratory capacity and function in healthy individuals and in burn victims for up to 2 years postinjury. Muscle biopsies were collected from 16 healthy men and from 69 children with burns encompassing at least 30 percent of their total body surface area. Seventy-nine biopsies ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Measuring depression in adults with burn injury: A systematic review

This systematic review of the literature was conducted to identify evidence to support the use of measures of depression for adults with burn injuries. The goal was to determine the most reliable, valid, and efficient means of identifying adults with symptoms of depression including major depressive disorder. Established guidelines ...
Northwest Regional Burn Model System
Publication Year
2016

Morbidity and mortality in severely burned children with clostridium difficile-associated diarrhea

Study investigated the effect of Clostridium difficile-associated diarrhea (CDAD) on morbidity and mortality in severely burned children and identified CDAD risk factors. After retrospective review of 2,840 records, 288 pediatric burn patients were identified as having diarrhea, defined as stool output of more than 10 milliliters per kilogram per ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Pathophysiology, research challenges, and clinical management of smoke inhalation injury

Article reviews the current understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management. Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. Despite recent advances in critical care and the ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Pediatric contractures in burn injury: A burn model system national database study

Study examines the incidence and severity of contractures in a large, multicenter, pediatric burn population and determined the associated risk factors for the development of contractures. Data from the National Institute on Disability and Rehabilitation Research Burn Model System database, for pediatric (younger than 18 years) burn survivors from ...
Boston-Harvard Burn Injury Model System
Publication Year
2016

Predicting heterotopic ossification early after burn injuries: A risk scoring system

This study developed a scoring system that stratifies burn patients at the time of hospital admission according to risk of developing heterotopic ossification (HO), the development of abnormal bone in the soft tissue. HO in burns is an uncommon but severely debilitating problem with a poorly understood mechanism and ...
Boston-Harvard Burn Injury Model System
Publication Year
2016

Propranolol reduces cardiac index but does not adversely affect peripheral perfusion in severely burned children

Study examined the effect of propranolol on hemodynamic parameters assessed using the PiCCO (Pulse index Continuous Cardiac Output) system in burned children. The study analyzed hemodynamic data from 121 patients who were randomized to receive either propranolol or placebo (control), which was initiated as a prospective randomized controlled trial. ...
Pediatric Burn Injury Rehabilitation Model System
Publication Year
2016

Reversal of growth arrest with the combined administration of oxandrolone and propranolol in severely burned children

Study investigated whether the combined administration of oxandrolone and propranolol attenuates growth arrest and improves the rate of growth, compared to the administration of oxandrolone or propranolol alone, in severely burned children. In this prospective, randomized study of 612 burned children (males between the ages of 0.5 and 14 ...
Pediatric Burn Injury Rehabilitation Model System

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  • 2004 (10)
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Participating Centers

  • Boston-Harvard Burn Injury Model System (63)
  • Georgia Model Brain Injury System (GAMBIS) (1)
  • Johns Hopkins University Burn Injury Rehabilitation Model System (46)
  • North Texas Burn Rehabilitation Model System (36)
  • Northwest Regional Burn Model System (83)
  • Pediatric Burn Injury Rehabilitation Model System (161)
  • Spaulding-Harvard Traumatic Brain Injury Model System (1)
  • UCHSC Burn Model System Data Coordination Center (BMS/DCC) (2)

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The contents of this site were developed under grant number 90DPKT0009 from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR). NIDILRR is a Center within the Administration for Community Living (ACL), Department of Health and Human Services (HHS). The contents of this website do not necessarily represent the policy of NIDILRR, ACL, HHS, and you should not assume endorsement by the federal government.