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Study investigated the effect of Clostridium difficile-associated diarrhea (CDAD) on morbidity and mortality in severely burned children and identified CDAD risk factors. After retrospective review of 2,840 records, 288 pediatric burn patients were identified as having diarrhea, defined as stool output of more than 10 milliliters per kilogram per ...

Study examined the incidence of single- or multiple-organ failure and its resultant clinical outcomes during acute hospitalization in pediatric burn patients. Patient outcomes are inherently dependent on intact organ function; however, burn injury affects the structure and function of almost every organ, but especially lung, liver, kidney, and heart. ...

Study investigated whether the coadministration of oxandrolone and propranolol alters plasma propranolol concentrations. Propranolol, is a beta blocker used to reduce resting heart rate and cardiac work caused by elevated circulating catecholamines. Oxandrolone, a testosterone mimetic, promotes protein synthesis and anabolism to counter muscle wasting; testosterone administration is known ...

Article reviews the current understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management. Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. Despite recent advances in critical care and the ...

This article calls for physicians to implement patient-reported outcome measures (PROMs) into their practice and for researchers to study their potential value in the clinical setting. PROMs are powerful tools that can bridge the need for data-driven patient information while also strengthening the physician-patient connection. When maximized in clinical ...

Study examines the incidence and severity of contractures in a large, multicenter, pediatric burn population and determined the associated risk factors for the development of contractures. Data from the National Institute on Disability and Rehabilitation Research Burn Model System database, for pediatric (younger than 18 years) burn survivors from ...

This study developed a scoring system that stratifies burn patients at the time of hospital admission according to risk of developing heterotopic ossification (HO), the development of abnormal bone in the soft tissue. HO in burns is an uncommon but severely debilitating problem with a poorly understood mechanism and ...

Study investigated whether expression of interleukin 8 (IL-8), a major mediator for inflammatory responses, can be used to predict post-burn sepsis, infections, and mortality. Plasma cytokines, acute-phase proteins, constitutive proteins, and hormones were analyzed during the first 60 days after injury from 468 pediatric burn patients. Demographics and clinical ...

Study identified factors associated with long-term insulin resistance in pediatric burn injury survivors. The study sample consisted of 61 pediatric burn injury survivors 24 to 36 months after the burn injury, who underwent an oral glucose tolerance test. To assess insulin resistance, the authors calculated the area under the ...

Study examined the skeletal muscle protein synthesis (MPS) rate of burned children over a period of 24 months after injury and identified predictors that influence this response. Eighty-seven children with 40 percent or greater total body surface area (TBSA) burned participated in stable isotope infusion studies at 1, 2, ...

What is a urinary tract infection? A urinary tract infection (UTI) is an infection in your urinary system. This system includes your kidneys, ureters, bladder, and urethra. What causes UTI? The most common cause of UTI starts when bacteria enter the bladder through the urethra. The bacteria may multiply in the bladder to ...

Study investigated whether wound healing and perioperative hemodynamics are affected by propranolol administration in severely burned adults. Sixty-nine adult patients with burns covering at least 30 percent of their total body surface area received standard burn care, 35 patients with and 34 without (controls) propranolol. Propranolol was administered within ...

Study examined the effect of propranolol on hemodynamic parameters assessed using the PiCCO (Pulse index Continuous Cardiac Output) system in burned children. The study analyzed hemodynamic data from 121 patients who were randomized to receive either propranolol or placebo (control), which was initiated as a prospective randomized controlled trial. ...

Study evaluated the psychometric properties of the 4-dimension (4-D) itch scale, a modified version of the 5-dimension itch scale, in a sample of individuals with severe burn injury and/or burn injuries to hands, face, and/or feet. Four of the five domains of the 5-dimension itch scale (4-D) were administered ...

Study examined long-term psychological distress and quality of life (QOL) in young adult survivors of pediatric burns using the World Health Organization Disability Assessment Scale II (WHODAS) and the Burn Specific Health Scale-Brief (BSHS-B). The WHODAS measures health and disability and the BSHS-B measures psychosocial and physical difficulties. Fifty ...

This 5-year prospective multicenter study included 152 adults with burn injuries, ages 19 to 30 years, who completed the Young Adult Burn Outcome Questionnaire (YABOQ) up to 36 months after injury. The YABOQ measures 15 patient-reported outcomes including physical, psychological, and social statuses and symptoms such as itch and ...

Study examined the relationship between long-term functional recovery and total body surface area (TBSA) burned. Data were analyzed for 147 burned subjects who completed the Young Adult Burn Outcome Questionnaire at initial baseline contact, 2 weeks, and at 6 and 12 months after initial questionnaire administration. One hundred twelve ...

Study compared the rehabilitation outcomes of burn patients admitted to an inpatient rehabilitation facility (IRF) who were discharged to acute care and then readmitted to an IRF (repeaters) with those of burn patients admitted to an IRF only 1 time (nonrepeaters). A secondary analysis was performed of data from ...

Article highlights a core set of foundational themes that are needed to develop the next decade of rehabilitation research priorities to optimize burn recovery. These themes include: integrating burn survivors into rehabilitation research, measuring the right things, utilizing technology, learning from other fields of medicine, translating bench research to ...