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Study explored whether intensive insulin therapy is associated with improved post-burn morbidity and mortality. A total of 239 severely burned children with burns over more than 30 percent of their total body surface area were randomized to intensive insulin treatment or control. Demographics, clinical outcomes, sepsis, glucose metabolism, organ ...

Study examined the effects of an intensive insulin therapy protocol in an acute pediatric burn unit and the mechanisms underlying its benefits. Twenty children, 4 to 18 years old, with total body surface area burned greater than 40 percent and who arrived within 1 week after injury were included ...

Article provides an overview of the current month’s edition of SHOCK, which presents a diverse range of outstanding clinical and basic science investigations. Topics include: prediction of morbidity and mortality after trauma, burns, and sepsis through physiological, inflammatory, cellular, and genetic patterns; stem cell cardioprotection; hemorrhage control through nerve ...

Study measured insulin resistance in severely burned children whose wounds were 95 percent healed. Twenty-four children, aged 4 to 17 years, with total burn surface area equal to or greater than 40 percent underwent a 2-hour oral glucose tolerance test before discharge from the acute pediatric burn unit. Plasma ...

Study tested the hypothesis that thermal injury depletes body stores of vitamin E by measuring concentrations of a-tocopherol concentrations in adipose tissue samples obtained from children with burn injuries. Adipose tissue a-tocopherol concentrations are generally accepted to reflect long-term vitamin E deficiency. Eight pediatric patients were followed up to ...

Article discusses the epidemiology and risk factors, mechanisms of injury, clinical assessment, and methods of prevention associated with pediatric burn injuries. Burns are the third most frequent cause of childhood injury resulting in death, behind motor vehicle accidents and drowning. Burn injuries account for the greatest length of stay ...

Article reviews evidence from clinical and laboratory research studies exploring the use of virtual reality (VR) to control pain in burn patients undergoing painful medical procedures. VR analgesia has been demonstrated in burn patients both during daily wound care and during physical therapy. Burn patients report 35 to 50 ...

Study reports the differential transcriptome over time and the functional genomics unique to Week 20 post wounding from the deep cones/fat domes in the Duroc/Yorkshire porcine model of fibroproliferative scarring following shallow and deep partial thickness wounds. A system was assembled that permits the study of genome-wide gene expression ...

Study assessed psychometric properties of the brief COPE (BCOPE) in hospitalized patients with burn injury. The BCOPE is a 28-item measure developed from the full-version COPE inventory (60 items) to provide an efficient means of assessing coping behaviors. A total of 362 participants admitted to the hospital with a ...

Study investigated the role of the melanocortin 1 receptor (MC1R) and its ligand a-melanocyte-stimulating hormone (a-MSH) in the regulation of inflammatory and fibroproliferative responses to cutaneous injury. Specifically, the authors report the localization of the MC1R/a-MSH signaling in murine cutaneous wounds, human acute burns, and hypertrophic scars. During murine ...

Study examined workers who were hospitalized with work-related burn injuries and their psychiatric sequelae in Washington State. Psychiatric sequelae of interest were depression, posttraumatic stress disorder, and other anxiety disorders. Workers' compensation claims for burn patients from Washington State hospitalized from January 2001 through April 2008 were identified. The ...

The purpose of this study was to investigate the recovery of burn-related neuropathies by electrodiagnostic testing. Burn patients who presented to an American Burn Association verified burn center were interviewed and examined for clinical evidence of peripheral neuropathies by a physiatrist. Patients whom consented to participate were tested for ...