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HYPOTHESIS: Obesity in?uences metabolism and increases the incidence of clinical complications and worsens outcomes in pediatric burn patients. DESIGN: Retrospective, single-center study. SUBJECTS: In all, 592 severely burned pediatric patients who had burns covering more than 30% of the total body surface area and who were treated between 2001 ...

BACKGROUND: Patient survival after severe burn injury is largely determined by burn size. Modern developments in burn care have greatly improved survival and outcomes. However, no large analysis of outcomes in paediatric burn patients with present treatment regimens exists. This study was designed to identify the burn size associated ...

BACKGROUND: Burn induces a hypermetabolic state characterized by alterations in protein metabolism, which is associated with increased morbidity and mortality. Eukaryotic elongation factor 2 (eEF2) plays a crucial role in regulating protein synthesis in many diseases, but whether it participates in burn-induced hypermetabolism is unclear. The aim of this ...

Fenofibrate is a peroxisome proliferator activated receptor alpha agonist that contains both pro and anti-inflammatory properties, and has been used in the treatment of dyslipidemia and diabetes for decades. Its receptors are expressed in the liver, skeletal muscle, cardiac, enteric, and renal cells, which allow it to provide systemic ...

Study investigated self-reported postburn pruritus (itching) in two groups of adult burn survivors. Descriptive statistics, general linear regression, and mixed model repeated measures analyses were used to test statistical significance. Group 1 consisted of 637 participants who were injured from 2006 to 2010 and were followed up prospectively for ...

Article reviews changes in burn care at the Harborview Burn Center in Seattle, WA, from 1974 to 2009. It reports results and include observations on changes in numbers of standard and short-stay admissions, age distribution, transport patterns, percent of total body surface area burned, race/ethnicity, payer status, fluid creep, ...

OBJECTIVE: Severe thermal injury induces inflammatory and hypermetabolic responses that are associated with morbidity and mortality. However, it is not well-documented whether the causes of burns affect inflammation, hypermetabolism, and morbidity. The aim of the present study was to determine whether there is a difference in degree of inflammation, ...

Study examined the long-term functional and psychological outcomes of older adults after burn injury. The authors analyzed the outcomes of 737 patients aged 55 years or older who were enrolled and followed in the National Institute on Disability and Rehabilitation Research burn program. Change in living situation as well ...

Study examined the organization and current practices in physical rehabilitation across burn centers. An online survey was used to collect information regarding: (1) logistics of the burn center, (2) inpatient and outpatient treatment of patients with burn injury, and (3) specific protocols in the treatment of a few complications ...

Study examined the effects of exercise training on resting energy expenditure (REE) during the rehabilitation of severely burned pediatric patients. Severe burns cause profound hormonal and metabolic disturbances resulting in hypermetabolism, reflected in extreme elevation of REE and extensive skeletal muscle catabolism. Twenty-one patients (aged 7 to 17 years) ...

Study examined the thermoregulatory response of burned children to exercise in the heat. Ten children with greater than 40 percent total body surface area burns and 10 non-burned children performed a 30-minute session of treadmill exercise at 75 percent of their peak aerobic power in a heated environment. Intestinal ...

Study determined which glucose levels are associated with improved morbidity and mortality in thermally injured children. Two-hundred eight pediatric patients with burns over 30 percent of their total body surface area were included in this trial. Several statistical models were used to determine the daily average and 6 AM ...

Study compared a low fat/high-carbohydrate diet and a high-fat diet on morbidity and mortality outcomes in severely burned children. Nine hundred forty-four children with burns on 40 percent or more of their total body surface area (TBSA) were divided into two groups: 518 patients receiving Vivonex T.E.N. (low-fat/high-carbohydrate diet) ...

This review article discusses the more recent advances in therapeutic strategies to attenuate the hypermetabolic response and its associated insulin resistance postburn. The hypermetabolic response in critically ill patients is characterized by hyperdynamic circulatory, physiologic, catabolic, and immune system responses. Failure to satisfy overwhelming energy and protein requirements after, ...

Study examined the impact of face burns on the psychosocial adjustment of pediatric burn survivors and their parents during the first two years after injury. Subjects were 390 children less than 18 years old at injury, admitted for burn treatment from September 2001 to December 2004. Psychosocial functioning was ...

Study implemented a four-step process to evaluate the measurement properties of the Perceived Stigmatization Questionnaire (PSQ) and the Social Comfort Questionnaire (SCQ) among long-term pediatric burn survivors. Participants included 369 pediatric and 347 adult burn survivors. First, a series of confirmatory factor analyses compared the hypothesized four-factor model comprising ...

Study compared perceptions of stigmatization experienced by 85 pediatric burn survivors with those of their parents. Among the burn survivors, 38 percent were female, 44 percent had facial scars, and the median number of surgical procedures was two. Survivors and a parent independently completed the Perceived Stigmatization Questionnaire (PSQ), ...

Study examined the effect of a steady state amino acid (AA) infusion on leg muscle protein turnover and whole-body muscle and whole-body nonmuscle protein breakdown rates in pediatric burn patients at 6 month postinjury compared with that of healthy subjects. A total of 10 pediatric patients and 5 healthy ...

Study evaluated whether oxandrolone treatment affects mechanisms of protein turnover in skeletal muscle in response to amino acid (AA) infusion and on whole-body protein breakdown in pediatric burn patients 6 months postinjury. At the time of admission, patients were randomized to control or oxandrolone treatments. Clinically, oxandrolone has been ...

Study examined the ability of insulin to improve outcome following a Pseudomonas aeruginosa wound infection in a rodent model of severe burn injury. Burn-injured Sprague Dawley rats were randomized into treatment groups that received either saline or insulin. Burn wounds were topically inoculated with a lethal dose of Pseudomonas ...