Model System:

Burn

Reference Type:

JA

Accession No.:

Journal:


Pediatric Crit. Care Med

Year, Volume, Issue, Page(s):

, 12, 6, 275-281

Publication Website:

Abstract:

OBJECTIVE:
Severe thermal injury induces inflammatory and hypermetabolic responses that are associated with morbidity and mortality. However, it is not well-documented whether the causes of burns affect inflammation, hypermetabolism, and morbidity. The aim of the present study was to determine whether there is a difference in degree of inflammation, hypermetabolism, endocrine and acute-phase response, and clinical outcome between pediatric patients with scald and flame burns.
INTERVENTIONS:
None.
MEASUREMENTS AND MAIN RESULTS:
Children with burns requiring surgical intervention were enrolled in this cohort study and divided into two groups, scald or flame burn. In a second assignment, we analyzed the study populations in representative subgroups containing individuals with third-degree burns of 40% to 60% total body surface area. We determined clinical outcomes, resting energy expenditures, cytokine profiles, acute-phase proteins, constitutive proteins, and hormone panels. Statistical analysis was evaluated by analysis of variance, Student's t test corrected with the Bonferroni post hoc test, and the propensity score. Statistical significance was set at p CONCLUSION:
The type of burn affects hypermetabolism, inflammation, acute-phase responses, and mortality postburn.

Author(s):


Kraft R.A., Kulp G.A., Herndon D.N., Emdad, F., Williams F.N., Hawkins H.K., Leonard K.R., Jeschke M.G.

Participating Centers: