Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children

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Study examined the effects of an intensive insulin therapy protocol in an acute pediatric burn unit and the mechanisms underlying its benefits. Twenty children, 4 to 18 years old, with total body surface area burned greater than 40 percent and who arrived within 1 week after injury were included in the data analysis. Patients were randomized to one of two groups: (1) intensive insulin therapy maintained blood glucose levels between 80 and 110 milligrams per deciliter (mg/dL) or (2) conventional insulin therapy maintained blood glucose

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