Impaired glucose tolerance in pediatric burn patients at discharge from the acute hospital stay

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Study measured insulin resistance in severely burned children whose wounds were 95 percent healed. Twenty-four children, aged 4 to 17 years, with total burn surface area equal to or greater than 40 percent underwent a 2-hour oral glucose tolerance test before discharge from the acute pediatric burn unit. Plasma glucose and insulin levels as well as the Homeostasis Model Assessment for Insulin Resistance (HOMAIR) were compared with published oral glucose tolerance test data from healthy, non-burned children. There was a significant difference between severely burned children and non-burned, healthy children with respect to the HOMAIR. Severely burned children had a HOMAIR of 3.53 compared with the value in non-burned, healthy children of 1.28. The results of this study warrant future investigations into therapeutic options for the burned child during the rehabilitative phase of their care after injury.

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