Model System:

Burn

Reference Type:

Journal

Accession No.:

J78251

Journal:


Shock

Year, Volume, Issue, Page(s):

, 46, 5, 486-491

Publication Website:

Abstract:

Study examined the effect of propranolol on hemodynamic parameters assessed using the PiCCO (Pulse index Continuous Cardiac Output) system in burned children. The study analyzed hemodynamic data from 121 patients who were randomized to receive either propranolol or placebo (control), which was initiated as a prospective randomized controlled trial. Endpoints were cardiac index (CI), percent predicted heart rate (%HR), mean arterial pressure (MAP), percent predicted stroke volume (%SV), rate pressure product (RPP), cardiac work (CW), systemic vascular resistance index (SVRI), extravascular lung water index (EVLWI), arterial blood gases, events of lactic acidosis, and mortality. Mixed multiple linear regressions were applied, and a 95-percent level of confidence was assumed. Groups were comparable in demographics, EVLWI, SVRI, %SV, arterial blood gases, Denver 2 post injury organ failure score, incidence of lactic acidosis, or mortality. The percent predicted HR, MAP, CI, CW, and RPP were significantly reduced in the propranolol-treated group. Results indicate that propranolol significantly reduces cardiogenic stress by reducing CI and MAP in children with severe burn injury. Although, peripheral oxygen delivery, events of lactic acidosis, and organ dysfunction was not higher in propranolol treated patients.

Author(s):


Wurzer, Paul, Branski, Ludwik K., Clayton, Robert P., Hundeshagen, Gabriel, Forbes, Abigail A., Voigt, Charles D., Andersen, Clark R., Kamolz, Lars-P., Woodson, Lee C., Suman, Oscar E., Finnerty, Celeste C., Herndon, David N.

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