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Study investigated whether the combined administration of oxandrolone and propranolol attenuates growth arrest and improves the rate of growth, compared to the administration of oxandrolone or propranolol alone, in severely burned children. In this prospective, randomized study of 612 burned children (males between the ages of 0.5 and 14 ...

Study investigated the fractional synthesis rate (FSR) and fractional breakdown rate (FBR) in the skeletal muscle of 42 severely burned pediatric patients for up to 1 year after injury. Skeletal muscle protein kinetics were measured in the postprandial state following bolus injections of phenylalanine stable isotopes. Plasma and muscle ...

Study explored whether trajectories of common biomedical markers of metabolism and inflammation can be utilized to determine survival in pediatric burn patients. A total of 230 severely burned children with burns exceeding 30 percent of their total body surface, requiring at least 1 surgical procedure were enrolled in this ...

BACKGROUND: The National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) Burn Injury Model Systems (BMS) is a nationwide database that uses patient-reported outcome measures to collect data. Though the outcome measures demonstrate good psychometric properties, the question remains whether or not these measures collect data that encompass ...

Article discusses the psychometric properties and clinical utility of the Burn Outcome Questionnaires (BOQs). The BOQs are currently the most well-studied and clinically developed patient-reported outcome measures for use in children with burn injuries. There are currently four separate BOQ instruments: (1) the BOQ0–5, administered to the parents of ...

Study assessed how lower-body burn locations affected strength and cardiopulmonary function. Children who participated in an exercise study between 2003 and 2013, were 7-18 years of age, and burned ≥30 percent of their total body surface area were included. Analysis of variance was used to model the relationship of ...

This is the first installment of a three-part series exploring the stress response to severe burn trauma. This article reviews the current literature pertaining to the pathophysiological stress response to burn trauma, and the leading therapies to mitigate this response. Focus will be placed on recent advances that have ...

This article examines the output from each Burn Model System (BMS) component over the past 20 years. The National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR) established the BMS in 1993 to improve the lives of burn survivors. The BMS program includes: (1) a multicenter longitudinal database ...

Article reviews the evidence for the utility of rehabilitative exercise training (RET) in restoring physiological function in burn survivors. Severe burn trauma results in persistent skeletal muscle catabolism and prolonged immobilization. The authors hypothesize that structured RET is a safe and effective strategy to restore lean body mass and ...

Study compared cardiac output (CO) measurements performed in severely burned children using the transpulmonary thermodilution (TPTD) with the PiCCO (Pulse index Continuous Cardiac Output) system or transthoracic echocardiography (TTE). Fifty-four severely burned children were studied. Outcomes were compared using t-tests, multiple linear regression, and a Bland-Altman plot. An analysis ...

Heterotopic ossification (HO) is the pathologic development of ectopic bone in soft tissues because of a local or systemic inflammatory insult, such as burn injury or trauma. In HO, mesenchymal stem cells (MSCs) are inappropriately activated to undergo osteogenic differentiation. Through the correlation of in vitro assays and in ...

Study used latent growth curve and longitudinal structural equation modeling to examine the 2-year trajectory of satisfaction with appearance in adults with burn injury, and that trajectory’s effect on depression 5 years after burn injury. Data on the Satisfaction With Appearance Scale and Patient Health Questionnaire-9 (depression) were collected ...

Study investigated the impact of severe burn injury on skeletal muscle mitochondrial function and coupling control in adult humans. Mitochondria are the cellular organelles responsible for almost all oxygen consumption in vivo. It was hypothesized that severe burn injury alters skeletal muscle mitochondrial function, favoring mitochondrial thermogenesis. This hypothesis ...

Study evaluated the utility of telemedicine during the rehabilitative phase of burn care. Telemedicine is defined as the use of information technology to deliver health care at a distance. A retrospective review was performed on patients enrolled in a program that utilized telemedicine between a burn center and rehabilitation ...

Study assessed the psychometric properties of the full-version Community Integration Questionnaire (CIQ-15) in the adult burn population. Data were obtained from a multicenter longitudinal data set of 492 burn survivors. The questionnaire items were evaluated for clinical and substantive relevance; validation procedures were conducted on different samples of the ...

Study analyzed the variation in rehabilitation utilization by state of hospitalization for patients hospitalized with burn injury. This retrospective cohort study used nationally collected data over a 10-year period (2001 to 2010), from the Healthcare Cost and Utilization Project State Inpatient Databases. A total of 57,968 patients hospitalized for ...

Article reviews the history of burn care and rehabilitation from the perspective of leaders in the field of physical medicine and rehabilitation (PM&R). Although burn rehabilitation is a requirement of residency training in PM&R and burn topics are included on the national board examination, PM&R residents are not choosing ...

Study investigated whether the Vancouver Scar Scale (VSS) can be used to define hypertrophic scarring (HTS) in an objective, reliable manner. An online survey sent to 1,000 burn care providers asked respondents what VSS score indicates HTS and asked them to score scar photos using the VSS. Receiver operating ...

Study evaluated the efficacy of utilizing an expanded care coordinator (ECC) to supplement existing outpatient burn rehabilitation services. In this between-group, single-blind, randomized controlled trial, the 41 patients in the control group received standard outpatient care and the 40 experimental group patients received additional services provided by the ECC, ...

Study identified predictors for discharge to independent versus non-independent living status in older patients hospitalized for burns. Patient, injury, and treatment outcomes data were collected from 591 patients aged ≥55 years who were treated and discharged alive from three burn centers participating in the Burn Model Systems project from ...