Model System:

Burn

Reference Type:

Journal

Accession No.:

J75731

Journal:


Shock

Year, Volume, Issue, Page(s):

, 44, 5, 397-401

Publication Website:

Abstract:

Study investigated the fractional synthesis rate (FSR) and fractional breakdown rate (FBR) in the skeletal muscle of 42 severely burned pediatric patients for up to 1 year after injury. Skeletal muscle protein kinetics were measured in the postprandial state following bolus injections of phenylalanine stable isotopes. Plasma and muscle phenylalanine enrichments were quantified using gas chromatography-mass spectrometry. Results indicated that the FSR in burn patients was 2- to 3-times higher than values from healthy men previously reported in the literature. The FBR was 4- to 6-times higher than healthy values. Therefore, net protein balance was lower in burn patients compared to healthy men from 2 weeks to 12 months post injury. These findings show that skeletal muscle protein turnover stays elevated for up to 1 year after burn, an effect attributable to simultaneous increases in FBR and FSR. Muscle FBR exceeds FSR during this time, producing a persistent net negative protein balance, even in the postprandial state, which likely contributes to the prolonged cachexia seen in burned victims.

Author(s):


Chao, Tony, Herndon, David N., Porter, Craig, Chondronikola, Maria, Chaidemenou, Anastasia, Abdelrahman, Doaa R., Bohanon, Frederick J., Andersen, Clark, Sidossis, Labros S.

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