Model System:

Burn

Reference Type:

Journal

Accession No.:

J78254

Journal:


Annals of Surgery

Year, Volume, Issue, Page(s):

, 264, 3, 421-428

Publication Website:

Abstract:

Study investigated whether the combined administration of oxandrolone and propranolol attenuates growth arrest and improves the rate of growth, compared to the administration of oxandrolone or propranolol alone, in severely burned children. In this prospective, randomized study of 612 burned children (males between the ages of 0.5 and 14 years and females between the ages of 0.5 to 12 years), subjects were assigned to one of four treatment groups. The children received one of the following treatments during their acute stay and for 1 year post discharge: (1) control treatment, (2) oxandrolone alone, (3) propranolol alone, or (4) combined administration of oxandrolone and propranolol. Data were recorded at discharge, 6 months, and 1 and 2 years post injury. The duration of growth arrest was defined as the days from the date of burn to the date at which each subject was determined to have passed their admission height by at least 0.25 centimeters and where the height increase was persistent and progressive. Growth rate was measured in centimeters grown per year. The results indicated that combined use of oxandrolone and propranolol shortened the period of growth arrest by 84 days and increased growth rate by 1.7 centimeters per year, compared to controls. It is concluded that combined administration of oxandrolone and propranolol attenuates burn-induced growth arrest in pediatric burn patients.

Author(s):


Herndon, David N., Voight, Charles D., Capek, Karel D., Wurzer, Paul, Guillory, Ashley, Kline, Andrea, Andersen, Clark R., Klein, Gordon L., Tompkins, Ronald G., Suman, Oscar E., Finnerty, Celeste C., Meyer, Walter, Sousse, Linda E.

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