Importance: Traumatic brain injury (TBI) leads to 2.9 million visits to US emergency departments annually and frequently involves a disorder of consciousness (DOC). Early treatment, including withdrawal of life-sustaining therapies and rehabilitation, is often predicated on the assumed worse outcome of disrupted consciousness.
Objective: To quantify the loss of consciousness, factors ...
Abstract
Dopaminergic (DA) system function is frequently disrupted after traumatic brain injury (TBI). However, published interventions that target the DA system with the hope of enhancing functional outcomes are inconclusive, partially because of the lack of DA signaling biomarkers that can be used to select patients likely to benefit from DA-directed ...
Study determined the time course to recovery of communication after severe brain injury. One hundred seventy-five patients admitted to rehabilitation with severe acquired brain injury and no evidence of communication were evaluated using the Coma Recovery Scale-Revised (CRS-R). Researchers analyzed the time from injury to recovery of intentional communication (IC, ...
Study tested the following hypotheses: (1) a positive feedback relationship exists between acute serum tumor necrosis factor-alpha (TNFa) and estradiol (E2), and (2) acute concentrations of E2 and TNFa are prognostic indicators of death after severe traumatic brain injury (TBI). Severe TBI activates a robust systemic response that involves inflammatory ...
Study explored the impact of traumatic brain injury (TBI) on the quality of life (QoL) and self-concept of Spanish-speaking immigrants with TBI in the United States (US). Semi-structured interviews on QoL and self-concept following TBI were conducted with 24 Spanish-speaking Hispanic immigrants with TBI living in the community in the ...
Study estimated the probability of returning to productivity over the 5 years following moderate-to-severe traumatic brain injury (TBI). A secondary longitudinal analysis was conducted using individual growth curve analysis based on a sample of 2,542 population-weighted individuals with a primary diagnosis of TBI who were engaged in school or work ...
Study assessed the responsiveness of the Traumatic Brain Injury-Quality of Life (TBI-QOL) measurement system. Two hundred one adults with traumatic brain injury (TBI) from 3 TBI Model Systems rehabilitation centers completed the 20 TBI-QOL item banks and the Participation Assessment with Recombined Tools-Objective (PART-O) Productivity Subscale at baseline and 6-month ...
Article offers recommendations intended to reduce the rate of opioid misuse and overdose for a particularly high-risk group of people with traumatic brain injury (TBI). A consensus process conducted with TBI researchers and expert practitioners developed practical recommendations to inform prescribing of opioids for people with TBI. After determining key ...
Article describes the content and development of an active control condition for an evidence-based intensive lifestyle intervention (ILI) for weight-loss after traumatic brain injury (TBI) – the Group Lifestyle Balance intervention. Intervention studies should incorporate strong scientific designs and active control conditions to assess effectiveness and aid in replication. Despite ...
Growing evidence suggests that individuals with traumatic brain injury (TBI) may be uniquely susceptible to opioid misuse and the consequences of opioid use disorder (OUD). Multiple independent risk factors (e.g., high rates of chronic pain, pre- and post-injury substance misuse, injury-related neurobehavioral changes, overprescribing of opioids, and barriers in access ...
Study investigated the relationship between three language-dependent behaviors (command-following, intelligible verbalization, and intentional communication) and the functional status of patients with disorders of consciousness (DoC). It was hypothesized that patients in minimally conscious state (MCS) who retain behavioral evidence of preserved language function would have similar levels of functional disability, ...
Study examined the associations of specific physical and neuropsychiatric medical conditions with the trajectory of motor and cognitive functioning and life satisfaction over the first 10 years following traumatic brain injury (TBI). Participants were 404 individuals with TBI who were enrolled in the TBI Model System longitudinal study and had ...
Study examined the relationship between history of traumatic brain injury (TBI) and loneliness and identified mediators of that relationship. Data from the Health and Retirement Study were analyzed for a nationally representative sample of 724 adults over age 50 years. Loneliness was evaluated using the 11-item Revised University of California ...
Study examined the interrelationships between postinjury employment and substance abuse (SA) among individuals with traumatic brain injury (TBI). Structural equation model (SEM) and logistic regression analyses used a merged data from the National Trauma Data Bank (NTDB) and the Traumatic Brain Injury Model Systems (TBIMS) National Database. A total of ...
The objective of this study was to conduct a scoping review on classifications of mild stroke based on stroke severity assessments and/or clinical signs and symptoms. Electronic searches of PubMed, PsycINFO (Ovid), and Cumulative Index to Nursing and Allied Health (CINAHL–EBSCO) databases included keyword combinations of mild stroke, minor stroke, ...
This review summarizes early empirical findings that provide a context for integrating more recent clinical and research observations regarding impaired self-awareness (ISA) and denial of disability in post-acute traumatic brain injury (TBI). While several empirical studies have appeared on ISA after TBI over the last 20 years, the relative role ...
Study examined heterogeneity in the temporal patterns of depression and participation over the first 2 years after traumatic brain injury (TBI). Data were analyzed for 2,307 people with TBI enrolled in the TBI Model Systems database, who had follow-up conducted primarily by telephone at 1 year and 2 years post ...
Study identified the factors associated with the remission of insomnia by examining a sample of individuals who had insomnia within the first two years after traumatic brain injury (TBI) and assessing their status at a secondary time point. Data were collected from individuals enrolled in TBI Model Systems National Database ...
Study examined the effectiveness of the Therapeutic Couples Intervention (TCI), designed to improve relationship quality for couples after acquired brain injury. Composed of 5 to 6 two-hour sessions, the TCI is a manualized, treatment program designed to enhance relationship quality by addressing issues and concerns most often identified by persons ...