A theoretically derived minimal clinically important difference for clinical trials in patients with disorders of consciousness

Model System:

TBI

Reference Type:

Journal article

Accession No.:

J86569

Journal:

PsyArXiv Preprints

Year, Volume, Issue, Page(s):

2021 , , ,

Publication Website:

Abstract:

Assessing the minimal clinical change that a patient would perceive as beneficial is impossible in unconscious and non-communicative patients. The authors propose a novel probability-based approach to developing a minimal clinically significant change for the two most commonly used scales in patients with disorders of consciousness: the Coma Recovery Scale – Revised and the Disability Rating Scale.

Author(s):

Spivak, Norman M. |Edlow, Brian L. |Bodien, Yelena G. |Monti, Martin M.|