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This study is investigating a non-invasive method of brain stimulation (Transcranial Direct Current Stimulation- tDCS) for the relief of chronic pain and itch due to a previous burn injury. This is a double-blind, randomized controlled trial. During tDCS, we use a small, handheld, battery-powered device to induce a low ...

In this study, we propose to conduct a randomized controlled trial to test the efficacy of a client- and community-centered intervention for caregivers of persons with traumatic brain injury (TBI) consisting of education and mentoring in solving caregiver and brain injury related problems affecting everyday life. The intervention will ...

The overall aim of this project is to develop user friendly, methodologically high quality models for prediction of a number of important outcomes following TBI. These outcomes will include neuropsychological status, functional status (including employment), emotional functioning, perceived quality of life, and post-traumatic symptoms. Prediction of outcome in individual ...

The proposed research focuses on the challenging problem of post-traumatic irritability (primary aim) and aggression (secondary aim) using a comprehensive, rigorous approach to generate and disseminate new knowledge on this high impact, pervasive, and under-studied problem that affects approximately 29-71% of individuals with traumatic brain injury (TBI). Our approach ...

The Mayo Clinic TBIMS is conducting one site specific research project for the 2007-2012 NIDRR funding cycle, the Midwest Advocacy Project (MAP). MAP is the first randomized practical behavioral trial of its kind and intends to scientifically test the efficacy of advocacy training for individuals with TBI and their ...

This project is a cross-national collaboration with a specialty TBI service in a Copenhagen hospital, with which we share many similarities in terms of patient mix, treatment philosophy and cultural milieu. However, the Copenhagen facility provides significantly longer and in some respects, more intensive inpatient care and rehabilitation compared ...

This project is a placebo-controlled pilot study of the effects of dextroamphetamine (DEX) on attention, engagement in therapy, cognitive and motor speed, and other outcomes in subacute TBI. We will also examine the possibility that DEX accelerates the pace of functional recovery in the subacute phase. ...

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At present, clinical judgment and experience guide diagnostic, prognostic and treatment decisions for individuals with DOC. However, we continue to struggle with diagnostic error, misinterpretation of behavioral findings, inability to predict functional outcome in individual cases, and uncertainty regarding the neural mechanisms of recovery. When combined with behavioral observations, ...

This project extends our prior investigations of the effectiveness of specialized, post-acute brain injury rehabilitation. In order to understand the contribution of postacute rehabiltiation to rehabilitation outcomes, we must first answer the question of how to characterize the course of post-acute brain injury rehabilitation, and its impact on the ...

Overview: In this project the utility of aerobic exercise as a treatment of post-TBI fatigue (PTBIF) is being examined. The study will advance our understanding of the benefits of exercise by examining improvements in mood and cognition, in addition to fatigue, as they relate to exercise, as well as ...

Overview: This is a study of the relationship between sleep architecture (depicting an individual's phases of sleep as well as other characteristics of sleep) and post-TBI fatigue (PTBIF), using polysomnography (PSG), with spectral analysis and multi-stage survival analysis. The aim of the study is to further our understanding of ...

This treatment study is a double-blind, placebo controlled trial designed to determine if treatment with recombinant human growth hormone (rhGH) in the sub-acute period after TBI results in improved functional outcome after injury and to determine if: treatment with rhGH results in increased IGF-1 levels; benefits of rhGH treatments ...

The hypothesis of this project is that a novel imaging technique, Diffusion Tensor Magnetic Resonance Imaging (DTI), Resting State fMRI, and Susceptibility Weighted Imaging may be more reliable indicators of Diffuse Axonal Injury (DAI) than standard structural MRI. Being able to identify specific subtypes of traumatic brain injury (TBI) may ...

An online resource for those needing detailed information and support in regards to outcome measures for brain injuries. The measures included in the COMBI are commonly used in the field of brain injury rehabilitation and assessment.

The purpose of this research study is to evaluate the efficacy of a 12 week home-based walking program in ameliorating common secondary conditions or complications which occur after acquiring a Traumatic Brain injury

The purpose of this study is to examine the efficacy of a cognitive rehabilitation program that aims to improve new learning and memory in people with moderate to severe learning impairment due to traumatic brain injury. Participants will consist of 120 individuals who have sustained a traumatic brain injury ...

The purpose of this study is to evaluate the efficacy of a specific, replicable community based treatment intervention that addresses health and wellness issues using goal setting and a problem solving approach, in a group format for individuals with TBI using a randomized wait-list control group design. Four hypotheses will ...