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  • Projects

    Atomoxetine (Strattera) for the Treatment of Attention Disorders in Individuals with TBI

    Atomoxetine (Strattera), a selective norepinephrine reuptake inhibitor, is the only medication that is currently approved for the treatment of attention deficit hyperactivity disorder (ADHD) in adults by the Food and Drug Administration (FDA). It has gained considerable interest as an alternative medication for treating TBI-related attentional problems and related sequelae; ...
  • Projects

    A Randomized, Controlled, Single-masked Clinical Trial of Interpersonal Process Recall (IPR) in the Rehabilitation of Social Communication Abilities for Persons with TBI

    Overview: This study is a clinical trial of a treatment designed to improve social communication skills after traumatic brain injury (TBI). Persons with TBI who have completed inpatient brain injury rehabilitation, are approximately one year after their injury and show evidence of social communication difficulties after their injury may be ...
  • Projects

    Use of Enhanced Financial Incentives to Improve Work Attendance in Persons with TBI and Substance Use Disorders

    The purpose of this project is to determine if deficits in decision making are associated with outcomes at 3, 6, and 12 months after initiation of supported employment services. While supported employment has generally been found to be an effective approach for most populations, unqualified effectiveness with all persons ...
  • Projects

    The Effect of Visual Perceptual Training on Screening for Driving Using the Useful Field of View Test Following Moderate to Severe TBI

    This study focuses on people aged 19-59 sustaining moderate to severe traumatic brain injury who exhibit difficulty with visual processing speed based on Useful Field of View (UFOV) test performance. After consent these people are randomly assigned to a visuo-perceptual speed training program (Posit Science Insight) or standard treatment ...
  • Projects

    Acute Cognitive and Neurobehavioral Intervention: Efficacy Evaluation with Families

    Lengths of stay in inpatient rehabilitation following brain injury have declined over the last decade. Concerns have been expressed that many patients are discharged home to family members who are inadequately equipped to help. Increased stress is a common challenge faced by family members in the early days after ...
  • Projects

    Evaluation of an Intervention Model for Family Crisis and Support

    The rehabilitation community has for many years recognized family members' valuable role in caring for persons with TBI during the course of rehabilitation and recovery. Helping family members to cope more effectively has the potential to improve outcomes for persons with TBI. Strengthening families can enable persons with brain ...
  • Projects

    Traumatic Brain Injury, Acupuncture and Insomnia Study

    The Midwest Regional Traumatic Brain Injury Model System (MRTBIMS) has been created to accomplish several important objectives in support of an interdisciplinary, multidimensional center focused on providing and improving care for people with TBI. We will establish a coordinated multilevel interdisciplinary system of care for people with traumatic brain ...
  • Sexuality and Intimacy After Burn Injury

  • Projects

    A Virtual Environment Intervention for Improving Attention in TBI

    Although repetitive attention training for cognitive rehabilitation has shown to be effective for traumatic brain injury (TBI), training involves considerable time and attention from the therapist and sadly this resource is often limited three hours per day even though a majority of patients could tolerate more. Virtual reality (VR) ...
  • Projects

    TBI Model System Collaborative Study of Amantadine for Post TBI Irritability and Aggression

    The study focuses on the challenging problem of post-traumatic irritability (primary aim) and aggression (secondary aim). Irritability and Aggression are a high impact, pervasive, and under-studied problem that affects approximately 29-71% of individuals with traumatic brain injury (TBI). The current literature does not support Standards or Guidelines for the ...
  • Projects

    Individualized Planning for the First Year Following Acute Rehabilitation Project

    The Individualized Planning for the First Year Following Acute Rehabilitation Project is a multi-center research partnership among the Ohio Regional TBI Model System, the Institute for Clinical Outcomes Research in Salt Lake City, Utah, and the TBI Model Systems National Data and Statistical Center and the Rocky Mountain Regional ...
  • Projects

    Measuring Quality of Life in Traumatic Brain Injury: the Next Generation of Instruments (TBI-QOL)

    Objective: The scarcity of traumatic brain injury (TBI) -specific quality of life (QOL) measurement tools hinders the efforts of TBI intervention researchers, whose goal is to obtain valid and useful data to evaluate new treatment approaches. The goals of this study are to use the Kessler Foundation's expertise in ...
  • Projects

    Pathways of Post-Acute Rehabilitation

    This study characterizes the referral patterns and types of services provided after discharge from acute rehabilitation.
  • Projects

    Characterizing Mild Traumatic Brain Injury

    This study examines the incidence of TBI Model System participants who meet diagnostic criteria for mild TBI and their associated symptom profiles.
  • Projects

    A Multicenter Prospective Randomized Controlled Trial of the Effectiveness of Amantadine Hydrochloride in Promoting Recovery of Function Following Severe Traumatic Brain Injury

    After severe traumatic brain injury (TBI) some people remain unconscious or minimally conscious for weeks or months, and sometimes permanently. Severe disorders of consciousness prevent such individuals from regaining independence in self-care, communication, and mobility. Many different treatments have been recommended to promote recovery from severe brain injury, including ...
  • Projects

    Acupuncture for the treatment of insomnia in traumatic brain injury

    We intend to demonstrate that acupuncture is an effective means of treating insomnia in patients with traumatic brain injury. Further, acupuncture has a more favorable side-effect profile than most commonly used insomnia medications, and we expect to see this translate into improved cognitive and affective (mood) outcomes. ...
  • Projects

    Double-Blind, Placebo-controlled Trial of Amantadine Hydrochloride in the Treatment of Chronic TBI Irritability and Aggression: A Replication Study

    Irritability is reported by both individuals with TBI and their families as the most common of the permanent post-TBI personality and behavioral issues. Irritability can be highly disruptive socially and at work, a major family burden, and an interference to receiving appropriate care. In severe cases, behaviors may be ...
  • Projects

    Use of SMS Messaging to Promote Emotional Health for People With Traumatic Brain Injury: A Randomized Controlled Trial

    Emotional distress is a significant problem for people with TBI, but few empirically validated treatments are available. Behavioral Activation (BA) is a promising model for TBI because it is conceptually simple, involving translation of important life values into the planning of activities that, by the theory underpinning BA, should ...
  • What People are Saying about MSKTC

    Share your story   "As someone who has been living with quadriplegia and a speech disability for over 18 years, I always felt that I was navigating an unfamiliar terrain. For many, many years, I found myself alone in my journey trying to find answers to questions and better understand my ...
  • Projects

    Development of a Pain Assessment Measure for Severe Brain Injury

    Conditions causing pain are common after traumatic brain injury, but many patients with moderate/severe brain injury are unable to cooperate with typical pain assessment procedures that require identifying the location of pain and numerically grading its severity. This may result in excessive diagnostic procedures to search for a source ...

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Information on this site is not meant to replace the advice of a medical professional. You should consult your health care provider regarding specific medical concerns or treatment. The contents of this site were developed under grant number 90DPKT0009 from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR). NIDILRR is a Center within the Administration for Community Living (ACL), Department of Health and Human Services (HHS). The contents of this website do not necessarily represent the policy of NIDILRR, ACL, HHS, and you should not assume endorsement by the federal government.