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This multi-center module project will build upon our expertise in life course epidemiology, geospatial indicators of social determinants of health, and outcome modeling. We will collect new data on early life circumstances, which to date has been virtually unexplored in the TBIMS despite substantial evidence of impact on adult brain health. Our recent work additionally uncovered vast potential for using census tract-level data linkages to characterize participants' current environment; we will now use these methods to create neighborhood-level indicators of key social determinants of health. While traditional predictor variables account for only a small proportion of variance in TBI outcomes, this study will significantly advance knowledge regarding how early life and concurrent environmental factors relate to injury outcome, paving the way for actionable targets of policy change and individualized care delivery.