Research About Predicting Outcomes of Disorders of Consciousness

In this video, Brian Edlow, MD, discusses what current research can—and cannot—tell us about predicting recovery after severe traumatic brain injury (TBI). Dr. Edlow explains how long‑term studies, many conducted through the Traumatic Brain Injury Model Systems, have reshaped our understanding of recovery. These studies show that recovery does not necessarily plateau at one year and can continue for many individuals over several years, including meaningful improvements in communication, independence, and return to school or work. While advances in research are improving our ability to understand recovery trajectories, Dr. Edlow emphasizes that accurate early prediction remains limited, underscoring the need for continued research and careful, humble communication with families facing uncertainty.

The content of this video is based on research and/or professional consensus. This content has been reviewed and approved by experts from the Traumatic Brain Injury Model System (TBIMS) centers, funded by the National Institute on Disability, Independent Living, and Rehabilitation Research, as well as experts from the Polytrauma Rehabilitation Centers (PRCs), with funding from the U.S. Department of Veterans Affairs. The content of the video has also been reviewed by individuals with TBI and/or their family members. 

Disclaimer: This information is not meant to replace the advice of a medical professional. You should consult your health care provider about specific medical concerns or treatment. The contents of this video were developed under a grant from the National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR grant number 90DPKT0009). NIDILRR is a Center within the Administration for Community Living (ACL), Department of Health and Human Services (HHS). The contents of this video do not necessarily represent the policy of NIDILRR, ACL, or HHS, and you should not assume endorsement by the federal government.

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