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Study investigated relationships between genetic variation that affects dopaminergic signaling and functional recovery at 6 and 12 months after traumatic brain injury (TBI). As dopamine neurotransmission impacts cognition, it was hypothesized that variants in the linked dopamine D2 receptor (DRD2) and ankyrin repeat and kinase domain (ANKK1) genes might ...

Study examined the relationship of depression and personal and injury characteristics to post-traumatic psychological growth (PTG) in 824 adults with spinal cord injury (SCI). PTG was measured using the Post-traumatic Growth Inventory, reflecting positive change after injury in life priorities, closeness to others, new opportunities being available, stronger faith, ...

Study determined the prevalence of posttraumatic stress disorder (PTSD) among racial/ethnic groups with spinal cord injury (SCI) and assessed the relationship of PTSD with demographic characteristics, injury-related characteristics, employment, depressive symptoms, and health events. A total of 1,063 participants with SCI were recruited from 3 sites in different regions ...

Study assessed the effects of amantadine on anger and aggression among 118 individuals with a chronic traumatic brain injury (TBI) enrolled in a parallel-group, randomized, double-blind, placebo-controlled trial. Participants were randomly allocated to take amantadine (100 mg every morning and noon) or a placebo equivalent for treatment of irritability. ...

This secondary analysis of a prospective, multi-center traumatic brain injury (TBI) registry examined the risk of institutionalization for individuals who sustained moderate and severe TBI and received inpatient rehabilitation. The study population included 7,219 patients with moderate-severe TBI in the Traumatic Brain Injury Model Systems National Database enrolled from ...

Study identified predictors of the severity of agitated behavior during inpatient traumatic brain injury (TBI) rehabilitation. Data were obtained from 2,130 patients admitted to 10 acute inpatient rehabilitation centers as part of a comparative effectiveness study in which patient characteristics, environmental factors, and interventions were evaluated to identify factors ...

Study examined driving behavior following traumatic brain injury (TBI) in terms of driving avoidance and exposure based on demographic, injury, and outcome factors. A total of 184 participants who experienced moderate to severe TBI completed a telephone survey regarding return to driving and current driving behavior. Structural equation modeling ...

Study examined the length of time to return to work (RTW) and identified variables predictive of RTW among service members and veterans (SM/V) with traumatic brain injury (TBI). Participants were 293 SM/V enrolled in the Department of Veterans Affairs (VA) TBI Model Systems study who were of 18 to ...

Study identified baseline participant variables in the domains of demographics, medical/psychosocial history, injury characteristics, and post-injury functional status associated with longitudinal follow-up completeness among participants with traumatic brain injury (TBI) using the TBI Model Systems (TBIMS) National Database (NDB). The sample analyzed included 8,249 individuals enrolled in the TBIMS ...

Study examined data from the second National Longitudinal Transition Study to identify variables associated with post-high school competitive employment, and to develop a logistic regression model for predicting successful employment outcomes. Data were analyzed for 2,900 special education students who exited high school in the 2002-2003 school year. The ...

Study identified preinjury coping profiles among adults with uncomplicated and complicated mild traumatic brain injury (mTBI) determined whether preinjury coping profiles contribute to the prediction of emotional functioning and quality of life (QOL) at 3 months post-mTBI. One hundred eighty-seven patients, including 89 with uncomplicated mTBI (i.e., negative neurological ...

Study examined whether pre-injury psychosocial and demographic factors differentially influence long-term functional outcomes following traumatic brain injury (TBI). Participants were 149 patients, ages 16–75, who sustained a mild complicated, moderate or severe TBI, were enrolled in a TBI Model System center, and had functional outcome data five to 15 ...

Study evaluated brain-derived neurotrophic factor (BDNF) as a biomarker for post-traumatic brain injury (TBI) depressions (PTD), cognitive impairment, and functional cognitive limitations in the first year following severe TBI. One hundred thirteen participants with TBI were evaluated for PTD using the Patient Health Questionnaire-9 (PHQ-9). Cognitive impairment using a ...

Study developed and provided initial validation of a measure for accurately determining the need for constant visual observation (CVO) in patients with traumatic brain injury (TBI) admitted to inpatient rehabilitation. An internally consistent measure of the need for CVO was developed and confirmed using Rasch analysis; the concurrent validity ...

Study examined whether subgroups of people with disabilities are more likely than people without disabilities to delay/forgo necessary care, in general and among the insured. Pooled Medical Expenditure Panel Survey data (2004-2010) were used to examine delaying or forgoing medical, dental, and pharmacy care among five disability subgroups (physical, ...

Study investigated the prevalence of all severities of traumatic brain injury (TBI), regardless of treatment setting, and their associated negative outcomes. A statewide, population-based, random digit-dialed telephone survey assessed the lifetime history of TBI in 2,701 adult Coloradoans, using a modified version of the Ohio State University TBI Identification ...

Study examined the prevalence of depression and suicidal behavior in a large cohort of patients who sustained moderate-to-severe traumatic brain injury (TBI). Data were obtained from patients who received acute care and comprehensive rehabilitation in a TBI Model Systems-designated brain injury inpatient rehabilitation program funded by the National Institute ...

Study examined the rate of clinically significant anxiety at 1 year after moderate-to-severe traumatic brain injury (TBI), specific symptoms of anxiety, risk factors for anxiety; and associations of anxiety with other 1-year outcomes, including participation and quality of life. Participants were 1,838 individuals with moderate-to-severe TBI who were enrolled ...