Journal:Archives of Physical Medicine and Rehabilitation
Year, Volume, Issue, Page(s):15, 96, 8, Supplement 3, S274-S281
Study identified predictors of the severity of agitated behavior during inpatient traumatic brain injury (TBI) rehabilitation. Data were obtained from 2,130 patients admitted to 10 acute inpatient rehabilitation centers as part of a comparative effectiveness study in which patient characteristics, environmental factors, and interventions were evaluated to identify factors associated with key TBI inpatient rehabilitation outcomes. This included 555 patients who exhibited agitation during their stay according to scores on the Agitated Behavior Scale. Potential predictors of the severity of agitation examined included patient and injury characteristics and comorbidities, and progress/changes in patient status throughout the rehabilitation stay. Results indicated that infection and lower Functional Independence Measure cognitive scores predicted more severe agitation. The medication classes associated with more severe agitation included sodium channel antagonist anticonvulsants, second-generation antipsychotics, and gamma-aminobutyric acid-A anxiolytics/hypnotics. Medication classes associated with less severe agitation included antiasthmatics, statins, and norepinephrine-dopamine-5 hydroxytryptamine (serotonin) agonist stimulants.