Model System:

TBI

Reference Type:

Journal

Accession No.:

J78473

Journal:


Neurodegenerative Disease Management

Year, Volume, Issue, Page(s):

, 6, 5, 417-429

Publication Website:

Abstract:

This scoping review summarizes clinical research from the past 10 years that evaluates the relationship between traumatic brain injury (TBI) and Alzheimer’s disease. This review identified five studies that found increased risk for dementia after TBI, two studies that found no increased risk, and four studies that found a relationship only under certain conditions or in specified subsamples. Methodological differences across studies preclude direct comparison of results, and discrepant findings elucidate the complex course of post-TBI neurodegeneration. The authors discuss the factors that influence the strength and direction of the relationship between TBI and Alzheimer’s disease, and the implications of this body of research for patient care and future research.

Author(s):


Dams-O'Connor, Kristen, Guetta, Gabrielle, Hahn-Ketter, Amanda E., Fedor, Andrew