Model System:

TBI

Reference Type:

JA

Accession No.:

J66681

Journal:


Journal of Neurology, Neurosurgery, and Psychiatry

Year, Volume, Issue, Page(s):

, 84, 2, 177-182

Publication Website:

Abstract:

Study investigated whether a self-reported lifetime history traumatic brain injury (TBI) with loss of consciousness (LOC) is associated with increased risk for subsequent late-life re-injury, dementia, and death. There were 4,225 dementia-free individuals age 65 and older randomly selected and enrolled between 1994 and 2010; 606 (14 percent) participants reported a lifetime history of TBI with LOC at enrollment. Participants were seen every 2 years. A total of 3,465 participants provided information regarding lifetime history of TBI and completed at least one follow-up visit. There were 25,567 person-years of follow-up data. Outcomes of interest include self-reported TBI with LOC after study entry, incident all-cause dementia and Alzheimer’s disease (AD), and all-cause mortality. History of TBI with LOC reported at study enrollment was associated with increased risk for TBI with LOC during follow-up, particularly among individuals whose first TBI with LOC was sustained after age 55. History of TBI with LOC was not associated with elevated risk for developing dementia or AD. There was no association between baseline history of TBI with LOC and mortality, though TBI with LOC since the previous study visit was associated with increased mortality. Findings support the need for close clinical monitoring of older adults who sustain a TBI with LOC.

Author(s):


Dams-O'Connor, K., Gibbons, L.E., Bowen, J.D., McCurry, S.M., Larson, E.B., & Crane, P.K.

Participating Centers: