Model System:

TBI

Reference Type:

Journal

Accession No.:

J78243

Journal:


Frontiers in Molecular Science

Year, Volume, Issue, Page(s):

, 10, 44,

Publication Website:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343043/

Abstract:

Study investigated the relationship between cerebrospinal fluid (CSF) cortisol and brain-derived neurotrophic factor (BDNF) as gene- and age-dependent biomarkers to predict mortality in 117 patients sampled within 6 days after severe traumatic brain injury (TBI). Researchers also determined associations between CSF cortisol and BDNF with 6-month mortality. BDNF variants, rs6265 and rs7124442, were used to create a gene risk score (GRS) in reference to previously published hypothesized risk for mortality in younger patients (

Author(s):


Munoz, Miranda J., Kumar, Raj G., Oh, Byung-Mo, Conley, Yvette P., Wang, Zhensheng, Failla, Michelle D., Wagner, Amy K.

Participating Centers: