Model System:

TBI

Reference Type:

Journal

Accession No.:

J73537

Journal:


Brain, Behavior, and Immunity

Year, Volume, Issue, Page(s):

, 45, , 253-262

Publication Website:

Abstract:

Study investigated the contribution of polytrauma to inflammatory profiles that occur with traumatic brain injury (TBI). Interleukin-6 (IL-6) is a pro-inflammatory cytokine known to be elevated after trauma, and a major contributor to the inflammatory response following TBI. Serial cerebrospinal fluid (CSF) samples were used to generate temporal acute IL-6 trajectory (TRAJ) profiles in a prospective cohort of 114 adults with severe TBI. Analysis examined the impact of injury type (isolated TBI versus TBI + polytrauma) on IL-6 profiles, and how IL-6 profiles impact sub-acute (2 weeks–3 months) serum inflammatory marker load and long-term global outcome 6–12 months post-injury. There were two distinct acute CSF IL-6 profiles, a high and low TRAJ group. Individuals in the high TRAJ had increased odds of unfavorable Glasgow Outcome Scale (GOS) scores at 6 months. Individuals in the high TRAJ also had higher mean acute CSF inflammatory load compared to individuals in the low TRAJ. The two groups did not differ with respect acute serum profiles; however, individuals in the high CSF IL-6 TRAJ also had higher mean sub-acute serum IL-1b and IL-6 levels compared with the low TRAJ group. Lastly, injury type was associated with IL-6 TRAJ group. Specifically, there was 70 percent concordance between those with TBI + polytrauma and the low TRAJ; in contrast, isolated TBI was similarly distributed between TRAJ groups. These data provide evidence that sustained, elevated levels of CSF IL-6 are associated with an increased inflammatory load, and these increases are associated with increased odds for unfavorable global outcomes in the first year following TBI.

Author(s):


Kumar, R. G., Diamond, M. L., Boles, J. A., Berger, R. P., Tisherman, S. A., Kochanek, P. M., Wagner, Amy K.

Participating Centers: