Role of agitation in prediction of outcomes after traumatic brain injury

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Study to determine the role of agitation in the prediction of traumatic brain injury (TBI) rehabilitation outcomes. Participants were 340 consecutive patients admitted to an acute TBI rehabilitation unit. Outcomes examined included rehabilitation length of stay (LOS), discharge destination, Functional Independence Measure (FIM) at discharge, productivity at one-year follow-up, and life satisfaction at one-year follow-up. Univariate analyses suggested that the presence of agitation in rehabilitation is predictive of a longer LOS, decreased FIM cognitive scores, and decreased likelihood of discharge to a private residence. However, multivariate analyses revealed that cognitive functioning at admission to rehabilitation (FIM cognitive) mediates the relationship between the presence of agitation and LOS, as well as between agitation and FIM cognitive at discharge. These results suggest that agitation and cognition are intimately related, with the long-term effects of agitation being at least parially driven by cognitive function. This document is included in NCDDR's Guide to Traumatic Brain Injury Resources Produced by NIDRR Grantees, number C.41.

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