Model System:

TBI

Reference Type:

Journal

Accession No.:

J76332

Journal:


Journal of the International Neuropsychological Society

Year, Volume, Issue, Page(s):

, 20, 6, 588-598

Publication Website:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103963/

Abstract:

Study evaluated the psychometric properties of the NIH Toolbox Cognition Battery (NIHTB-CB) composite scores in an adult sample. The NIHTB-CB was designed for use in epidemiologic studies and clinical trials for ages 3 to 85 years. The NIHTB-CB contains seven computer-based instruments assessing five cognitive sub-domains: language, executive function, episodic memory, processing speed, and working memory. A total of 268 healthy adults were recruited at four university-based sites, using stratified sampling guidelines to target demographic variability for age (20–85 years), gender, education, and ethnicity. Participants completed the NIHTB-CB, corresponding gold standard validation measures selected to tap the same cognitive abilities, and sociodemographic questionnaires. A subgroup of 89 participants completed a retest 7 to 21 days after initial testing to assess test–retest reliability and practice effects. Three cognition composite scores were derived for both the NIHTB-CB and gold standard measures: crystallized, fluid, and total. The NIHTB composite scores showed acceptable internal consistency, excellent test–retest reliability, strong convergent and discriminant validities versus gold standard composites, and expected age effects. Significant relationships with self-reported prior school difficulties and current health status, employment, and presence of a disability provided evidence of external validity. The NIHTB-CB composite scores have excellent reliability and validity, suggesting they can be used effectively in epidemiologic and clinical studies.

Author(s):


Heaton, Robert K., Akshoomoff, Natacha, Tulsky, David, Mungas, Dan, Weintraub, Sandra, Dikmen, Sureyya, Beaumont, Jennifer, Casaletto, Kaitlin B., Conway, Kevin, Slotkin, Jerry, Gershon, Richard

Participating Centers: