Diffusion Tensor Tractography of Traumatic Diffuse Axonal Injury

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Background: Diffuse axonal injury is a common consequence of traumatic brain injury that frequently involves the parasagittal white matter, corpus callosum, and brainstem. Objective: To examine the potential of diffusion tensor tractography in detecting diffuse axonal injury at the acute stage of injury and predicting long-term functional outcome. Design: Tract-derived fiber variables were analyzed to distinguish patients from control subjects and to determine their relationship to outcome. Setting: Inpatient traumatic brain injury unit. Patients: From 2005 to 2006, magnetic resonance images were acquired in 12 patients approximately 7 days after injury and in 12 age- and sex-matched controls.Main Outcome Measures: Six fiber variables of the corpus callosum, fornix, and peduncular projections were obtained. Glasgow Outcome Scale–Extended scores were assessed approximately 9 months after injury in 11 of the 12 patients. Results: At least 1 fiber variable of each region showed diffuse axonal injury–associated alterations. At least 1 fiber variable of the anterior body and splenium of the corpuscallosum correlated significantly with the Glasgow Outcome Scale–Extended scores. The predicted outcome scores correlated significantly with actual scores in a mixed-effects model. Conclusion: Diffusion tensor tractography–based quantitative analysis at the acute stage of injury has the potential to serve as a valuable biomarker.

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