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Accession No.:



Journal of Spinal Cord Medicine - JSCM (formerly Journal of the American Paraplegia Society)

Year, Volume, Issue, Page(s):

, 39, 5, 535-543

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Study examined the association of neuropathic and nociceptive pain severity with interference with quality of life (QoL) in people with spinal cord injury (SCI) who underwent a randomized controlled 12-week trial of an antidepressant to treat depression. A secondary objective was to assess the effect of changes in pain on mobility and physical independence. Of the 133 participants who were randomized into the trial, 108 provided pain severity and interference ratings through follow-up. QOL was measured using the Satisfaction with Life Scale and the physical and mental component summary scores of the 12-Item Short-Form Health Survey. Secondary outcome measures included the mobility and physical independence subscales of the Craig Handicap Assessment and Reporting Technique. Results revealed relationships between lower baseline nociceptive pain interference and higher satisfaction with life and mental health-related QoL at 12 weeks. Similarly, lower neuropathic pain interference was associated with change in physical independence, but unrelated to mobility. Few associations were found between pain and QoL. Findings suggest that pain interference over time may be differentially related to QoL outcomes based on the type of pain following SCI, but overall, there were no extensive relationships between pain and QoL in this sample of depressed individuals with SCI.


Richardson, Elizabeth J., Brooks, Larry G., Richards, J. Scott, Bombardier, Charles H., Barber, Jason, Tate, Denise, Forchheimer, Martin B., Fann, Jesse R.

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