Model System:

TBI

Reference Type:

JA

Accession No.:

J60027

Journal:


Journal of Neurotrauma

Year, Volume, Issue, Page(s):

, 25, 12, 1443-1440

Publication Website:

Abstract:

Traumatic brain injury (TBI) is a pathologically heterogeneous disease, including injury to both neuronal cell bodies and axonal processes. Global atrophy of both gray and white matter is common after TBI. This study was designed to determine the relationship between neuroimaging markers of acute diffuse axonal injury (DAI) and cerebral atrophy months later. We performed high-resolution magnetic resonance imaging (MRI) at 3 Tesla (T) in 20 patients who suffered non-penetrating TBI, during the acute (within 1 month after the injury) and chronic stage (at least 6 months after the injury). Volume of abnormal fluid-attenuated inversion-recovery (FLAIR) signalseen in white matter in both acute and follow-up scans was quantified. White and gray matter volumes were also quantified. Functional outcome was measured using the Functional Status Examination (FSE) at the time of the chronic scan. Change in brain volumes, including whole brain volume (WBV), white matter volume (WMV), and gray matter volume (GMV), correlates significantly with acute DAI volume (r¼ 0.69, 0.59, 0.58, respectively; p

Author(s):


Ding K., Marquez de la Plata C., Wang J.Y., Mumphrey M., Moore C., Harper C., Madden C.J., McColl R., Whittemore A., Devous M.D., Diaz-Arrastia

Participating Centers: