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This is a prospective study of health literacy in persons with complicated mild to severe TBI, its relationship to injury severity and cognitive impairments, and its contribution to health outcomes, including chronic health conditions, global health-related quality of life, depression, and anxiety. A random sample of English and Spanish speakers at 5 participating TBIMS centers will be selected from persons with TBI enrolled in the TBIMS national database and followed during the study period. Stratified random sampling will be used to ensure that persons selected are representative of the TBIMS national database in terms of education and race/ethnicity. Health literacy will be assessed using the Health Literacy Assessment Using Talking Touchscreen Technology (Health LiTT)- a 14-item multimedia assessment of document, quantitative, and prose health literacy. The results will be used to inform rehabilitation and other healthcare providers in tailoring their instructions and education to the health literacy of persons with TBI, and to inform development of a health literacy intervention for persons with TBI.