Short Tilte:Efficacy of amitriptyline for relief of pain in spinal cord injury: Results of a randomized controlled trial
Year, Volume, Issue, Page(s):02, 96, 3, 365-373
Study assessed whether amitriptyline, a tricyclic antidepressant, is effective in relieving chronic pain and improving pain-related physical and psychosocial dysfunction in people with spinal cord injury (SCI). Eighty-four participants with SCI and chronic pain were randomized to a 6-week trial of amitriptyline or an active placebo, benztropine mesylate. All pre- and post-treatment assessments were conducted by evaluators blind to the allocation. Regression analyses were conducted to examine whether there was a medication group effect on the primary (average pain intensity) and secondary outcome measures. No significant differences were found between the groups in pain intensity or pain-related disability post-treatment, in either intent-to-treat analyses or analyses of study completers. These findings do not support the use of amitriptyline in the treatment of chronic pain in this population.