Cardiometabolic changes and disparities among persons with spinal cord injury: A 17-year cohort study

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Study identified the magnitude of changes in biomarkers of cardiometabolic syndrome and diabetes over time in people aging with spinal cord injury (SCI), and determined how these biomarkers relate to demographics of race/ethnicity and sex. This cohort study was a 17-year follow-up of 150 participants from a full cohort of 845 adults with traumatic SCI who participated in research in which physiologic and serologic data on cardiovascular disease had been prospectively collected (1993-1997). Average years to follow-up were 15.7. Assessments were age, race, level and completeness of injury, duration of injury, blood pressure, body mass index, waist circumference, serum lipids, fasting glucose, hemoglobin A1c, and medications used. Primary outcome was meeting at least 3 of the criteria for cardiometabolic syndrome. Results showed that the frequency of cardiometabolic syndrome increased significantly from 6.7 percent to 20.8 percent or 38.2 percent, depending on the 2 diagnostic definitions used in the follow-up. It was significantly higher in Hispanics and apparently higher in women. Diabetes increased significantly by a factor of 6.7. These findings suggest that clinical practice guidelines need to be customized for women and Hispanics with SCI.

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