Bladder cancer mortality after spinal cord injury over 4 decades

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Study estimated bladder cancer mortality in people with spinal cord injury (SCI) compared to the general population. Data and statistics were obtained from the National SCI Statistical Center and the National Center for Health Statistics. The mortality experience of the 45,486 patients with traumatic SCI treated at a SCI Model System or Shriners Hospital was compared to the general population using a standardized mortality ratio. The standardized mortality ratio data were further stratified by age, gender, race, time since injury and injury severity. Analysis of 566,532 person-years of follow-up between 1960 and 2009 identified 10,575 deaths, and 99 were categorized as deaths from bladder cancer. The expected number of deaths from bladder cancer would have been 14.8 if patients with SCI had the same bladder cancer mortality as the general population. Thus, the standardized mortality ratio is 6.7. Increased mortality risk from bladder cancer was observed for various ages, races and genders, as well as for those injured for 10 or more years and with motor complete injuries. Bladder cancer mortality was not significantly increased for ventilator users, those with motor incomplete injuries or those injured less than 10 years. Individuals with SCI can potentially live healthier and longer by reducing the incidence and mortality of bladder cancer. Study findings highlight the need to identify at-risk groups and contributing factors for bladder cancer death, leading to the development of prevention, screening and management strategies.

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