Adiponectin is associated with bone strength and fracture history in paralyzed men with spinal cord injury

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Study investigated the relationship between circulating adiponectin levels and bone strength in 27 paralyzed men with spinal cord injury (SCI). Plasma adiponectin levels were quantified by ELISA assay. Axial stiffness and maximal load to fracture of the distal femur were quantified via finite element analysis using reconstructed three-dimensional models of volumetric computerized tomography scans. Information on the timing, location, and cause of previous fractures was also collected. Axial stiffness and maximal load were inversely associated with circulating adiponectin levels after adjusting for injury duration and lower extremity lean mass. In individuals with post-SCI osteoporotic fractures, distal femur stiffness and maximal load were lower, and adiponectin was higher than those with no fracture history. Results indicate that bone strength is inversely associated with circulating adiponectin levels. Based on these findings, strength estimates may improve fracture risk prediction and detection of response to osteogenic therapies following SCI. Furthermore, the findings suggest that circulating adiponectin may indeed be a feasible biomarker for bone health and osteoporotic fracture risk in paralyzed individuals with SCI.

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