Model System:


Reference Type:

Journal article

Accession No.:



Journal of Neurotrauma

Year, Volume, Issue, Page(s):

, 37, 1, 211-216

Publication Website:


Growing evidence suggests that individuals with traumatic brain injury (TBI) may be uniquely susceptible to opioid misuse and the consequences of opioid use disorder (OUD). Multiple independent risk factors (e.g., high rates of chronic pain, pre- and post-injury substance misuse, injury-related neurobehavioral changes, overprescribing of opioids, and barriers in access to care) converge for some individuals with TBI, creating a perfect storm of risk for OUD. Each of these factors is independently associated with OUD risk and adverse outcomes, but their convergence in this population makes people who have had a TBI uniquely vulnerable to opioid misuse and its devastating consequences. This perfect storm of converging risks and vulnerabilities may place individuals with TBI at risk not just for OUD, but for its most devastating outcomes. There is an urgent need to investigate the prevalence of short-term and long-term opioid medication use among people with TBI, and to understand the pathways to and prevalence of OUD in this population.


Sayko Adams, Rachel |Corrigan, John D. |Dams-O’Connor, Kristen|

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