Model System:

TBI

Reference Type:

Journal article

Accession No.:

J83444

Journal:

Experimental Neurology

Year, Volume, Issue, Page(s):

, 317, , 284-290

Publication Website:

Abstract:

Article utilizes a framework derived from the toxicology literature to determine whether a causal relationship exists between pediatric traumatic brain injury (TBI) and subsequent alcohol abuse. A potential causal relationship would only be likely if there is both strong epidemiological evidence for the relationship and a plausible biological relationship. In other words, this requires that an analogous mechanism exists in both a model system and in humans. If only one of the two classes of evidence is present then a causal relationship is unlikely. The article reviews the epidemiological evidence for increased drinking in humans. In addition, the animal models for increased drinking after TBI and the potential mechanistic insights that have been derived from those animal models are discussed. Based on the framework described, the authors conclude that it is possible that pediatric TBI causes alcohol use disorders later in life.

Author(s):

Weil, Zachary M. |Karelina, Kate |Corrigan, John D.|

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