Model System:

SCI

Reference Type:

Journal article

Accession No.:

J89299

Journal:

Nature Reviews. Neurology

Year, Volume, Issue, Page(s):

, 17, 1, 53-62

Publication Website:

Abstract:

Article describes the neuroanatomical–functional paradox in the context of traumatic spinal cord injury (SCI) and discusses the underlying mechanisms of the paradox, including the concepts of lesion-affected and recovery-related networks. This neuroanatomical–functional paradox is likely to contribute to the many failed attempts to independently replicate findings from animal models of neurotrauma. In humans, the analogous clinical–radiological paradox could explain why individuals with similar injuries can respond differently to rehabilitation. The authors also consider the various secondary complications that further limit the accuracy of outcome prediction in SCI and provide suggestions for how to increase the predictive, translational value of preclinical SCI models.

Author(s):

Fouad, Karim|Popovich, Phillip G.|Kopp, Marcel A.|Schwab, Jan M.|

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