Comparison of the gut microbiome composition among individuals with acute or long-standing spinal cord injury vs. able-bodied controls

Model System:

SCI

Reference Type:

Journal article

Accession No.:

J88873

Journal:

Journal of Spinal Cord Medicine - JSCM (formerly Journal of the American Paraplegia Society)

Year, Volume, Issue, Page(s):

2022 , 45, 1, 91-99

Publication Website:

Abstract:

Study compared the gut microbiome composition among 7 individuals with acute spinal cord injury (A-SCI) and 25 long-standing SCI (L-SCI) versus 25 able-bodied (AB) controls. Stool samples were collected after a median of 7 days and 18 years after injury in the A-SCI and L-SCI groups, respectively. Gut microbiome composition was analyzed using the 16S rRNA sequencing technique and QIIME software. The abundances of bacteria communities among groups were compared using the Kruskal–Wallis test adjusted for age. Results revealed differences in the gut microbiome composition among groups. Compared to the AB controls, the SCI groups demonstrated microbiome profiles that shared features linked to metabolic syndrome, inflammation-related bowel disorders, depressive disorders, or antibiotics use, whereas the L-SCI group’s microbiome included features linked to reduced physical activity compared to the A-SCI and AB controls. This study provided preliminary data and a scientific foundation for future studies investigating the impact of the gut microbiome composition on long-term health in individuals with SCI.

Author(s):