Model System:

SCI

Reference Type:

Journal article

Accession No.:

J88030

Journal:

Journal of Spinal Cord Medicine - JSCM (formerly Journal of the American Paraplegia Society)

Year, Volume, Issue, Page(s):

, 44, 6, 886-895

Publication Website:

Abstract:

Study examined the safety and effectiveness of micro-fragmented adipose tissue (MFAT) injections under ultrasound guidance for treatment of refractory shoulder pain caused by rotator cuff disease in wheelchair users with spinal cord injury (SCI). Ten wheelchair users with chronic SCI who had moderate-to-severe shoulder pain caused by refractory rotator cuff disease (diagnosed via ultrasound) for more than 6 months. Ultrasound-guided injections of MFAT into the pathologic rotator cuff tendons and other abnormal shoulder structures (e.g., acromioclavicular and glenohumeral joints; subacromial bursa). Six- and 12-month changes in 11-point Numerical Rating Scale (NRS), Wheelchair User’s Shoulder Pain Index (WUSPI), Brief Pain Inventory pain interference items (BPI-I7), Patient Global Impression of Change (PGIC), ultrasound and physical exams, and adverse events. There were no significant adverse events throughout the study period. WUSPI, NRS, and BPI-I7 scores were significantly lower 6- and 12-months post-procedure. Of those who remained in the trial, clinically meaningful changes (≥30 percent decrease) in WUSPI, NRS, and BPI-I7 scores were observed in 77.8, 77.8, and 66.7 percent of participants, respectively. All but one participant reported improvement in clinical status. Results suggest that MFAT injection under ultrasound guidance is potentially a safe and efficacious treatment for refractory shoulder pain caused by rotator cuff disease in wheelchair users with SCI. A larger, randomized controlled trial has been initiated.

Author(s):

Hogaboom, Nathan |Malanga, Gerard |Cherian, Chris |Dyson-Hudson, Trevor|

Participating Centers: