Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control, and mitochondrial function in children with burn injury

Model System:

Burn

Reference Type:

Journal article

Accession No.:

J81115

Journal:

American Journal of Physiology. Endocrinology and Metabolism

Year, Volume, Issue, Page(s):

2018 , 314, 3, E232-E240

Publication Website:

Abstract:

Study investigated whether a six-week exercise program combined with short-term metformin administration improves aerobic and strength exercise capacity to a greater degree than exercise and placebo, while improving glucose tolerance and muscle metabolic function. Children received placebo or metformin (500 mg, twice daily) at 72 to 96 hours after admission and participated in exercise training after discharge. At discharge and after six weeks of exercise training, cardiorespiratory function, strength and power, and body composition were determined. Results showed that six weeks of exercise rehabilitation improved strength and cardiorespiratory measures similarly in both groups. Metformin provided no additional benefit beyond that of exercise alone for strength, exercise capacity, and glycemic control.

Author(s):