Propranolol and oxandrolone therapy accelerated muscle recovery in burned children

Model System:

Burn

Reference Type:

Journal article

Accession No.:

J81122

Journal:

Medicine and Science in Sports and Exercise

Year, Volume, Issue, Page(s):

2018 , 50, 3, 427-435

Publication Website:

Abstract:

Study examined the effects of oxandrolone and propranolol (Oxprop) treatment during a 6-week rehabilitative exercise training (RET) program in severely burned children. In this placebo-controlled randomized trial, it was hypothesize that RET combined with oxandrolone and Oxprop will improve muscle mass and function and protein turnover in severely burned children compared with burned children undergoing the same RET with a placebo. Forty-two children (aged 7–17 years) with severe burns over 30 percent of the total body surface area were randomized to placebo (22 controls) or to Oxprop (20 patients) and began drug administration within 96 hours of admission. All patients began RET at hospital discharge as part of their standardized care. Muscle strength, power, peak oxygen consumption (VO2peak), body composition, and protein fractional synthetic rate and fractional breakdown rate were measured pre-RET (PRE) and post-RET (POST). Muscle strength and power, lean body mass, and VO2peak increased with RET in both groups. The increase in strength and power was significantly greater in Oxprop versus control, and strength and power was greater in Oxprop over control POST. Fractional synthetic rate was significantly higher in Oxprop than control POST, resulting in improved protein net balance POST. The findings indicate RET improves body composition, muscle function, and cardiorespiratory fitness in children recovering from severe burns and that Oxprop therapy augments RET-mediated improvements in muscle strength, power, and protein turnover.

Author(s):